Objectives Kalaf (Melasma) is an acquired facial hypermelanism. It has direct impact on patient’s quality of life and leads to development of various personality disorders. Lack of effective treatment and recurrences have drawn the attention of researcher to find alternative treatment. This study aimed to evaluate safety and efficacy of a topical Unani formulation in the management of melasma. Methods We conducted a prospective randomized controlled clinical study on the participants diagnosed with melasma. The participants (n=72) randomized into test (n=36) and control (n=36) groups. Sixty participants (n=30 in each group) completed the duration of therapy. The participants of the test group were treated with a classical Unani formulation and control group with hydroquinone 4%. The primary end point was change in mean MASI score and secondary end point was improvement in quality of life after eight weeks of treatment. Results The Unani formulation reduced 40.5% mean MASI score (17.31 ± 9.58 to 10.28 ± 5.92) in comparison to 32% reduction in mean MASI score (20.58 ± 9.49 to 13.92 ± 7.38) in the control group after eight weeks of treatment. When comparing with baseline the difference in MASI score was found statistically significant in both groups (p<0.05). On intergroup comparison, the change in MASI score between both groups was not statistically significant (p>0.05). In addition, MQOL and DQLI also improved significantly in both groups. Conclusions This study concluded that the Unani formulation and the control drug were equally effective and safer in the management of melasma.
Falij-e-Nisfi(Hemiplegia) is a condition in which there is loss of movement and sensation in longitudinal half of the either side of the body. It is the commonest form of paralysis, occurring due to stroke or cerebrovascular accident. Stroke is the leading cause of disability worldwide and second most common cause of death. Post stroke hemiplegia is most common causes of disability in adults. In India its prevalence is 56.9 per 100,000.Unani scholars from various part of the world have been treating the condition of Falij-e-Nisfi (Hemiplegia) since centuries successfully. Different effective regimes are available in Unani system of medicine (USM) for the treatment of Falij-e-Nisfi (Hemiplegia). Those treatments are effective and having fewer side effects. In the present paper the case studies of two female patients suffering from Falij-e-Nisfi(Hemiplegia) due to stroke treated with Unani formulations is reported. This case series documented the successful treatment and prevention of recurrence of hemiplegia through Unani medicines .It concluded that the Unani regimen was effective and safe in the management of hemiplegia.
Muqilis one of the best drugs in traditional system of medicine since ancient. It belongs to Burseraceae family, has 540 species and is found in dry area of India known as Indian bdellium. It is bushy plant 1.2-1.8 m can provide yellowish gum resin also called as gugulipid. Most commonly gum of this plant used for therapeutic and medicinal purpose. According to Unani system of medicine (USM) it has two types: 1. Muqil-e-Saqalibi, 2. Muqil-e-Arabi. The plant Commiphora mukul is also known as Balsamodendron mukul Stock. Muqil has active constituents producing number of biological activities such as Antiinflammatory effect (guggulsterones Z and E), Osteoprotective effect (guggulsterone), Anti- inflammatory, analgesic antiarthritic activities (Guggulsterone), Anti-diabetic effect (gum resin 900 mg daily), Antimicrobial, antibacterial, antiviral and antifungal activities (Eugenol, ellagic acid alpha-pinene, masumbinoic acid and masumbinone), Anti-hemorrhoid activity (Muqil resin), Anti-neoplastic activity (GS, gugulipid and Z-guggusterone), Cardioprotective effect (gugulipid and guggusterone), Nephroprotective effect, Nodulocystic Acne (Guggulipid), Neuroprotective effects (guggulipid), Immunomodulatory effect, Stimulate Thyroid gland activity (Commiphora mukul gum) Anti-asthmatic (300 mg of gum resin thrice daily), Inflammatory Bowel Disease (gum resin at a dose of 900 mg daily). It is also useful for systemic disease such as Osteoarthritis, Rheumatoid arthritis, Gout, Cadio-protective effect and thyro-protective effect, nervous diseases and urinarydiseases. Skin disorders are leprosy, pyorrhea, muscle spasm, demulcent, and depurative.
Borax is a mineral origin drug belongs to traditional system of medicine. It is a color less, translucent monoclinic crystalline with irregular shape. Chemically it is composition of boric acid and sodium. Its important component is Boron. It is also called as Sodium biborate. Borax contains 11.3% boron. Turkey is the largest source of borax about 73% of world. Vegetables, Fruits and salts are the main source of boron. Borax is used as a medicine because of its various therapeutic purposes such as Antimicrobial, Anticancer, Osteogenesis, Genotoxic, Vermicidal, Hemostatic, Analgesic and Healing properties. The information about this drug was extracted from traditional, modern drugs and electronic resources. Borax naturally present in crude form known as “sohagroo or tinkala”. After purification sohagroo called as Tankar (borax) and used for multiple therapeutic purposes. Borax is pentahydrate with specific gravity 1.73 having wide range of actions in Unani System of Medicine (USM) such as Jali(Cleanser/Detergent), Dafe-taaffun ( Antiseptic), Hazim ( Digestive), qatil-e-Jaraseem (Insecticides), Akkal (Corrosive), Munaffis-e-balgham (Expectorant), Mudir-e-hydz (Emmenogogue), Mudir-e-bowl (Diuretic), Kasir-i-Riyah (Carminative) and Daf-esamoom (Antidot). Traditionally used orally in the treatment of acidity, amenorrhea, dysmenorrhea, menorrhagia, puerperal convulsions (PIH). Locally beneficial for ulcers, piles, cystitis, leucorrhea, gonorrhea, cervical erosion also treat skin disease such as ringworm, acne, Pityriasis and melasma. Borax has temperament hot and dry temperament.
Falij-e-Nisfi (Hemiplegia) is a condition in which there is loss of movement and sensation in longitudinal half of the either side of the body. It is the commonest form of paralysis, occurring due to stroke or cerebrovascular accident. Stroke is the leading cause of disability worldwide and second most common cause of death. Post stroke hemiplegia is most common causes of disability in adults. In India its prevalence is 56.9 per 100,000.Unani scholars from various part of the world have been treating the condition of Falij-e-Nisfi (Hemiplegia) since centuries successfully. Different effective regimes are available in Unani system of medicine (USM) for the treatment of Falij-e-Nisfi (Hemiplegia). Those treatments are effective and having fewer side effects. In the present paper the case studies of two female patients suffering from Falij-e-Nisfi (Hemiplegia) due to stroke treated with Unani formulations is reported.This case series documented the successful treatment and prevention of recurrence of hemiplegia through Unani medicines. It concluded that the Unani regimen was effective and safe in the management of hemiplegia.
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