Early detection through screening of congenital hypothyroid is not a regular program of the government. so that cases of congenital hypothyroid can not be managed appropriately. Therefore, it needs to be done the research .about the benefits of the granting of a bloated fish containing omega-3 on congenital hypothyroid as a food supplement to stimulate nerve growth especially brain development. The sample of this research is the droppings of a white rat (Rattus norvegicus).The 30 rats are divided into 6 groups consisting of 5 rats. Four groups was induced with hypothyroid on the day 5 of gestation until nenonatus of the day 15, ..and two other groups .stayed normally.Thyroxine and mackerel meat were given on the 21st day after the birth until the 8th week. Histology and preparations werw made of cells Purkinje after being observed in the cerebellum. The number of Purkinje cells was analized with One-way Anova continued with multiple comparison test. The result is that the number of Purkinje cells in the normal group, normal + mackerel, hypothyroid, hypothyroid + mackerel, hypothyroid treatment with thyroxine, and thyroxine treatment with hypothyroid + mackerel are as follows: 60±12, 71±16, 40±6, 64±7, 70±5, and 65±20. The average number of Purkinje cells in the group that got mackerel significantly (p<0,05) increases compared to hypothyroid. The conclusion is that the supplementation of mackerel fish increases the number of Purkinje cells in the cerebellum of the rat with congenital hypothyroid.
Increased circulation, hormones, and energy metabolism due to exercise are thought to have a positive effect on nerve growth and development. This study aims to examine the effect of addition of sports games on IQ score, TSH, and BDNF levels of elementary school children in IDD endemic areas. This research method was a quasi-pretest-posttest control group design experiment. As many as 40 children aged 9 -11 years were divided into 19 children as controls, and 21 children doing sports games for 30 minutes per day, five times a week for eight weeks. Serum TSH and BDNF levels were measured using ELISA and IQ score using Culture Fear Intelligence Test (CFIT) method. Statistical analysis used was T-test, Wilcoxon, and Mann-Whitney test. The mean of serum TSH levels and IQ scores of the treatment group were not significantly different from those of the control group (p>0.05). The mean of BDNF levels in both groups increased significantly, and the increase in BDNF levels in the treatment group was greater than in the control group (p<0.05). It can be concluded that the addition of sports games did not significantly change TSH levels and IQ scores (p>0.05), but significantly increase BDNF levels (p<0.05).
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