Funding sources: None.Disclosure: Dr Wambier serves as an advisor for Young Pharmaceuticals, Inc, and has a patent application on the emulsification of phenole croton oil formulas. Drs Neitzke and de Grande Curi, Author Lin, and Drs Lee, Soon, Bittencourt, Aguiar, Neto, Filha, Beltrame, and D€ oll-Boscardin have no conflicts of interest to declare.IRB approval status: Reviewed and approved by the ethics committee of Hospital Heliopolis (no. 2.796.366).
A doença de Creutzfeldt-Jakob (DCJ) constitui-se na mais comum das doenças priônicas em seres humanos. Apresentamos um caso de DCJ tipo esporádico em um homem de 48 anos, que iniciou quadro de síndrome cerebelar, cuja clínica evoluiu compatível com DCJ associado à alteração do eletroencefalograma (EEG) típica e líquor (LCR) com alteração da proteína 14-3-3. São discutidos os métodos diagnósticos, as expectativas sobre a identificação de fatores de transmissão e a terapêutica atual.
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