Tujuan: Penelitian dilakukan dengan tujuan untuk mengetahui karakteristik faktor penyebab infertilitas pada pasangan yang menjalani in-vitro fertilization (IVF) di Klinik Bayi Tabung Rumah Sakit Umum Bali Royal Hospital periode Januari–Desember 2019. Metode: Penelitian ini adalah penelitian deskriptif observasional dengan populasi target penelitian adalah pasangan infertil yang datang ke Klinik Bayi Tabung Rumah Sakit Umum (RSU) Bali Royal Hospital dengan tindakan IVF pada tahun 2019. Data selanjutnya diolah berdasarkan karakteristik sampel, faktor istri, faktor suami, serta faktor lainnya. Hasil: Pada periode 1 Januari–31 Desember 2019, tercatat sebanyak 174 kasus pasien infertilitas. Pada penelitian ini diperoleh bahwa 60,23% terjadi gangguan pada tuba yang merupakan penyebab tertinggi pada kelompok istri, sedangkan gangguan sperma berupa oligoasthenoteratozoospermia (81,82%) merupakan hasil paling tinggi pada kelompok suami. kelainan lainnya yang mengganggu proses fertilisasi pada penelitian ini adalah terdapatnya kelainan uterus pada 23,36% pasangan. Kesimpulan: Faktor kelainan tuba dan oligoastenoteratozoospermia merupakan karakteristik penyebab terbanyak infertilitas pada pasangan yang dilakukan IVF Kata kunci: Infertilitas, IVF,Kelainan tuba, Oligoasthenoteratozoospermia
Background: Improving maternal and child health can be achieved through programs aimed at reducing maternal mortality rate (MMR) and infant mortality rate (IMR). Apart from going through a normal delivery, labor can also be done by abdominal surgery/ cesarean section (CS). A safe and timely Cesarean Section (CS) remains a major challenge in countries with high MMR, which poses new challenges to these countries in being able to minimize CS without clinical indication. This study aims to determine the rates and characteristics of patients underwent CS, indications of CS, as well as the rate of CS based on Robson's classification system.
Methods: A retrospective descriptive study of labor and delivery cases in the Sanglah General Hospital Denpasar was conducted from the period of 1stJanuary 2018 - 31st December 2018.
Results: From 1121 deliveries in 2018, the rates of CS in that period were 34.3%. As many as 28.1% were the age of 25-29 years. The 31.9% subjects were primigravida, with the gestational age was term around 66%. The majority of samples around 73.2% did not have a history of previous CS. Using Robson criteria, we found that the biggest contribution for CS rate was from group 10 (23.38%), then group 5 (15.84%) and group 2 (13.51%).
Conclusion: Around 385 cases of labor with CS were obtained from a total of 1121 deliveries in 2018 (34.3%). The highest rate was found in the age group of 25-29 years, mothers with first pregnancy (primigravida), most of the gestational age was term, majority did not have a history of previous CS and the highest contribution of CS rate was from Robson group 10 (23.38%).
BACKGROUND: Endometriosis cysts adversely affect a woman’s quality of life, which causes pain and reduces fertility. The World Health Organization found that the incidence of endometriosis with infertility clinical manifestations is around 10%.
AIM: The purpose of this study is to determine the presence of mice oocytes mitochondrial apoptosis exposed with endometriosis cysts follicular fluid through Bcl-2 and cytochrome C analysis.
METHODS: This study was a randomized post-test only control group design conducted at Sanglah Hospital, Bali Royal Hospital in Denpasar, and the Medical Faculty Udayana University from June 2018 to April 2019. A total of 120 mice oocytes were distributed randomly into three groups, i.e., treatment Groups 1 and 2 that added by 15% endometriosis cysts follicular fluid and control group. Bcl-2 and Cytochrome C analyzed with ELISA Technique. Comparability was tested with one-way ANOVA with a significance level of p < 0.05.
RESULTS: Eighteen mice oocyte replicates were normally distributed and homogeneous. The Bcl-2 levels in the treatment Groups 1, and 2 and control were 627.83 ± 146.42, 634.50 ± 140.62, and 678.83 ± 152.71, respectively; p = 0.838 (not significantly different). Cytochrome C levels in the treatment Groups 1, and 2, and control, respectively, were 3147.75 ± 228.50, 3104.45 ± 211.29, and 2738.28 ± 227.45; p = 0.021 (significantly different).
CONCLUSION: The effect of endometriosis cysts follicular fluid exposure on mitochondrial apoptosis is proven through Cytochrome C, whereas Bcl-2 is not proven.
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