Auditory event-related potentials (ERPs) during a syllable discrimination task were recorded from 15 patients suffering from methamphetamine (MAP) psychosis after the remission of acute psychotic symptoms, and from 15 normal age-matched controls. Subjects were instructed to press a button in response to the target syllables applied to one designated ear. In MAP psychotics, the attention-related negative components (Nd) area was reduced and P300 latency was delayed compared with normal controls. MAP psychotics and controls did not differ significantly in P300 amplitude. These findings suggest that MAP psychotics show some impairment in the auditory information processing.
Event-related potentials (ERPs) were recorded at the Cz, W1 (Wernicke's area), and W2 (contralateral to Wernicke's) regions in 27 schizophrenics during an auditory passive sequence paradigm similar to that employed by Polich. N1 component for frequent tones was analyzed. In schizophrenics, the difference between the ERP waveforms at W1 and W2 was larger than that in controls, and N1 latency at W1 was significantly shorter than that at W2. To examine the similarity between interhemispheric waveforms, Person product-moment correlation coefficient (Interhemispheric Correlation Coefficient, IHCC) was calculated, time point by time point, between the ERP waveforms at W1 and at W2. The mean IHCC for schizophrenics was significantly lower than that for controls. In schizophrenics, the low IHCC group had more severe psychopathology and a longer duration of illness. These results suggest that the hemispheric imbalance of the temporal lobe is characteristic of schizophrenia.
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