The prevalence of symptomatic RPN is low in this group of homozygous S patients and occurs more commonly in females. Improvement in care for these patients will reduce these chronic complications.
Presence of fusion the genes BCR/ABL1, ETV6/RUNX1, and MLL/AF4 does not have any impact on the clinical and laboratory features of ALL at presentation.
Childhood acute lymphoblastic leukaemia, (ALL) is increasingly reported to present in an atypical fashion which may have significant implications for treatment outcomes and survival. This case report presents a Nigerian child who's clinical and radiological features together with effusion cytological findings were suggestive of metastatic neuroblastoma. However, a definitive diagnosis of ALL was established following a bone marrow aspiration study that revealed abnormal cellularity consistent with L1 morphological subtype. Unfortunately, the child was discharged against medical advice before definitive therapy could be commenced.
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