Background: Recently, reports have described cases of the onset or exacerbation of psoriasis related to COVID-19 vaccination. In this study, we sought to describe the clinical features and evolutionary aspects of psoriasis exacerbation after COVID-19 vaccination. Materials and Methods: This was a prospective and descriptive study conducted over a period of eighteen months at the Department of Dermatology and Venereology of the Mohammed VI University Hospital in Marrakech. We included all patients followed for psoriasis who received at least one dose of Sinopharm, AstraZeneca, or Pfizer COVID-19 vaccine. Results: A total of 148 patients were included in the study, among which 69 received a Sinopharm vaccine, 48 received an AstraZeneca vaccine, and 31 received a Pfizer vaccine. The mean age was 49 years. There were 82 males and 66 females, giving a sex ratio of 1.6. The comorbidities included hypertension in 27.7% of the cases, diabetes in 14.8%, dyslipidemia in 10.8%, and thyroiditis in 2%. Eight exacerbations of psoriasis after COVID-19 vaccination were noted. The mean duration of lesion development was 11.5 days. The vaccines involved were Sinopharm in 5 patients and AstraZeneca in 3 patients. The median PASI before vaccination was 7.8 and the median PASI after vaccination was 20.5. Three patients presented with severe erythematous lesions requiring hospitalization and the introduction of systemic therapy. Extension of the lesions to localized psoriasis was noted in five patients. Conclusion: COVID-19 vaccination may be a trigger for psoriasis, as suggested by multiple studies. However, these events should in no way contraindicate vaccination in patients with psoriasis. Key words: vaccination; COVID-19; psoriasis; exacerbation
Fracture blisters are an uncommon complication that accompany high energy trauma. They are defined as tense vesicles overlying a fracture. Occurrence of these lesions alters and delays surgical management with higher risk of infection. Hence, most orthopedic surgeons recommend prompt stabilization of the fractures to reduce the of bullae formation. The authors describe an unusual case report of extensive fracture blisters and review of literature.
Carcinoma en cuirasse is a rare form metastatic cutaneous that characterized by a diffuse sclerodermoid induration of the mammary area, the chest and the abdomen. It is preferentially associated with a local recurrence of breast cancer after mastectomy, radiotherapy or chemotherapy. However, it can rarely be the initial clinical sign of breast carcinoma. The authors describe an unusual case report of primary breast carcinoma en cuirasse.
Kaposi’s sarcoma is an unusual multicentric malignant neoplastic disease, that characterized by the proliferation of spindle-shaped cells. This tumor is habitually involving in the skin of the lower extremities. However, it is rarely developing in the mucosa or skin of the head and neck. Herein, we report an uncommon presentation of Kaposi sarcoma affecting auricle,oral and ocula rmucosa in an immunocompetent patient. The diagnosis was made on clinical and histopathological finding.
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