The selective C–C bond cleavage and simultaneous formation of two C–F bonds and one C–S bond with DAST, CF3-DAST under metal-free/catalyst-free conditions is disclosed.
The intra-vs intermolecular transfer-fluoromethylation of aryl fluoromethylthio compounds is proposed. Finely designed ArSCF 3 (1a) nicely releases its trifluoromethyl (CF 3 ) group intermolecularly under rhodium catalysis, whereas a difluoromethylated analogue, ArSCF 2 H compound 1b shows intramolecular reaction.
A new organocatalytic asymmetric Michael addition reaction by cleavage of carboncarbon bonds through a mild release of trifluoroacetate has been developed. The reported method generates the decarboxylated g-nitro-a-fluorocarbonyl products with excellent enantioselectivies (up to 98% ee) and good diastereoselectivies (up to 20:1 dr).
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