The oxidation of catechol by molecular oxygen in the presence of a catalytic amount of copper(II) complex with 2-methyl-3-amino-(3H)quinazoline-4-one (MAQ) and various anions (Cl ) , Br ) , ClO 4 ) , SCN ) , NO 3 ) and SO 4 -) was studied. The catecholase biomimetic catalytic activity of the copper(II) complexes has been determined spectrophotometrically by monitoring the oxidative transformation of catechol to the corresponding light absorbing o-quinone (Q). The rate of the catalytic oxidation reaction was investigated and correlated with the catalyst structure, time, concentration of catalyst and substrate and finally solvent effects. Addition of pyridine or Et 3 N showed a dramatic effect on the rate of oxidation reaction. Kinetic investigations demonstrate that the rate of oxidation reaction has a first order dependence with respect to the catalyst and catechol concentration and obeying Michaelis-Menten Kinetics. It was shown that the catalytic activity depends on the coordination environment of the catalyst created by the nature of counter anions bound to copper(II) ion in the complex molecule and follows the order:To further elucidate the catalytic activity of the complexes, their electrochemical properties were investigated and the catecholase mimetic activity has been correlated with the redox potential of the Cu 2+ /Cu + couple in the complexes.