Anencephaly is a lethal fetal neurological malformation. This malformation accounts for 40% of neural tube malformations. The diagnosis is based on the ultrasound of the 1 st trimester between the 11 th and the 14 th weeks of amenorrhea by the discovery of an exencephaly which results in the visualization of the ossifi cation of the cranial box and therefore of the impossibility to measure the biparietaldiameter. The objective of our work is to highlight the importance of an early ultrasonic diagnosis of anencephaly, which could help in a thorough evaluation and active management. Also, the main role of folic acid in the prevention in neural tube defects.
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