Homocitrullylamino adenosine inhibits the incorporation of Ii4Clamino acids into a hot acid-insoluble form in cell-free systems derived from Escherichia coli and rat liver.The concentration necessary for one-half maximal inhibition in the E. coli system is i.l. Io -4 M. Addition of the intact molecule is necessary for the maximum inhibition. The inhibition does not appear to involve the activation of the amino acids or their transfer to s-RNA, but rather exerts its effect, like puromycin, at the level involving the s-RNA ribosomal complex.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.