Liposome-based delivery of BCH is capable of introducing sufficient boron to PC-3 cells for BNCT. High-LET α particles and (7)Li nuclei generated from (10)B thermal neutron capture significantly decrease colony formation ability in the targeted PC-3 cells.
The new nanodosimetry-based linear-quadratic (LQ) formula has been reviewed for mixed-LET irradiation. V-79 Chinese hamster cells have been irradiated with a mixed-LET field of fission neutrons and gamma rays at the University of Maryland Training Reactor (MUTR). The results show that the experimental survival curve agrees well with that predicted by the new nanodosimetry-based LQ model. The experimental study described in this note, therefore, serves as a validation for the new model to be used for mixed-LET radiotherapies, e.g. 252Cf brachytherapy.
International audienceRecent applications of high-LET radiation include boron neutron capture therapy. UV treatment of electron-irradiated UHMWPE impedes degradation caused by allyl radicals. Radiation synthesis of PVP nanogels above 55 1C leads to intra-molecular crosslinking. PCBs in contaminated sediments can be dechlorinated by reactions with hydrated electrons. a b s t r a c t Differences among the mechanisms of energy deposition by high-linear energy transfer (LET) radiation, consisting of neutrons, protons, alpha particles, and heavy ions on one hand, and low-LET radiation, exemplified by electron beam and gamma radiation on the other, are utilized in the selection of types of radiation used for specific applications. Thus, high-LET radiation is used for modification of carbon nanotubes, ion track grafting, and the synthesis of membranes and nanowires, as well as for characterization of materials by means of neutron scattering. Recent applications of low-LET irradiation include minimization of radiolytic degradation upon sterilization of ultra-high molecular weight polyethylene (UHMWPE), radiolytic synthesis of nanogels for drug delivery systems, grafting of polymers in the synthesis of adsorbents for uranium from seawater, and reductive remediation of PCBs
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