Episodic memory is believed to be intimately related to our experience of the passage of time. Indeed, neurons in the hippocampus and other brain regions critical to episodic memory code for the passage of time at a range of time scales. The origin of this temporal signal, however, remains unclear. Here, we examined temporal responses in the entorhinal cortex of macaque monkeys as they viewed complex images. Many neurons in the entorhinal cortex were responsive to image onset, showing large deviations from baseline firing shortly after image onset but relaxing back to baseline at different rates. This range of relaxation rates allowed for the time since image onset to be decoded on the scale of seconds. Further, the ensemble carried information about image content suggesting that neurons in the entorhinal cortex carry information not only about when an event took place but also the identity of that event. Taken together, these findings suggest that the primate entorhinal cortex uses a spectrum of time constants to construct a temporal record of the past in support of episodic memory.Episodic memory, the vivid recollection of an event situated in a specific time and place 1 , depends critically on medial temporal lobe (MTL) structures, including the hippocampus and entorhinal cortex (EC) 2-5 . Building on pioneering work demonstrating a spatial code in the hippocampus and entorhinal cortex 6,7 , recent research has shown that hippocampal representations also carry information about the time at which past events took place, suggesting that the MTL maintains a representation of spatiotemporal context in support of episodic memory [8][9][10] . Although a great deal is known about the temporal coding properties of neurons in the hippocampus, the temporal code in the entorhinal cortex, which provides the majority of the cortical input to the hippocampus is less understood, but see [11][12][13][14] .Hippocampal time cells provide a record of recent events including explicit information about when an event occurred. Analogous to hippocampal place cells that fire when an animal is in a circumscribed region of physical space 6, 15 , hippocampal time cells fire during a circumscribed period of time within unfilled delays 8,9,16 . Across studies, there is a remarkable consistency in the properties of hippocampal time cells. Hippocampal time cells peak at a range of times during the delay interval and typically code time with decreasing accuracy as the delay unfolds, as manifest 1 by fewer neurons with peak firing late in the delay and wider time fields later in the delay 12,17,18 . Hippocampal time cells have been observed in a wide range of behavioral paradigms, including tasks with and without explicit memory demands during the delay 17 and experiments in which the animal is fixed in space 19,20 . In addition, it has been shown that different stimuli trigger different time cell sequences 19,20 . Taken together, time cells provide an explicit record of how far in the past an event took place, i.e., the amount of time that h...
Episodic memory is believed to be intimately related to our experience of the passage of time. Indeed, neurons in the hippocampus and other brain regions critical to episodic memory code for the passage of time at a range of timescales. The origin of this temporal signal, however, remains unclear. Here, we examined temporal responses in the entorhinal cortex of macaque monkeys as they viewed complex images. Many neurons in the entorhinal cortex were responsive to image onset, showing large deviations from baseline firing shortly after image onset but relaxing back to baseline at different rates. This range of relaxation rates allowed for the time since image onset to be decoded on the scale of seconds. Further, these neurons carried information about image content, suggesting that neurons in the entorhinal cortex carry information about not only when an event took place but also, the identity of that event. Taken together, these findings suggest that the primate entorhinal cortex uses a spectrum of time constants to construct a temporal record of the past in support of episodic memory.
It is well-known that in free recall participants tend to recall words presented close together in time in sequence, reflecting a form of temporal binding in memory. This contiguity effect is robust, having been observed across many different experimental manipulations. In order to explore a potential boundary on the contiguity effect, participants performed a free recall task in which items were presented at rates ranging from 2 Hz to 8 Hz. Participants were still able to recall items even at the fastest presentation rate, though accuracy decreased. Importantly, the contiguity effect flattened as presentation rates increased. These findings illuminate possible constraints on the temporal encoding of episodic memories.
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