BackgroundDiarrhea associated with parvovirus infection is common in dogs. Supportive care is the mainstay of treatment, but recovery may be prolonged and mortality rate can be high. Modification of the intestinal bacterial microbiota has been promising in human and veterinary medicine as an adjunctive treatment of various enteric diseases.ObjectivesTo investigate the safety and efficacy of fecal microbiota transplantation (FMT) on the clinical recovery of puppies with acute hemorrhagic diarrhea syndrome.AnimalsSixty‐six puppies with parvovirus infection were evaluated at 2 veterinary hospitals.MethodsRandomized clinical trial. Puppies were randomly distributed into 2 groups: standard treatment (STD) and standard treatment + FMT (STD + FMT). The STD puppies (n = 33) received only treatment with IV fluids and antimicrobials and the STD + FMT puppies (n = 33) received FMT in addition to standard treatment. For FMT, 10 g of feces from a healthy dog diluted in 10 mL of saline were administered rectally 6‐12 hours post‐admission.ResultsAmong survivors, treatment with FMT was associated with faster resolution of diarrhea (P < .001) and shorter hospitalization time (P = .001; median, 3 days in STD + FMT; median, 6 days in STD) compared to standard treatment. Mortality in STD was 36.4% (12/33) as compared to 21.2% (7/33) in puppies treated with FMT, but there was no statistical difference between groups (P = .174). Polymerase chain reaction indicated that all animals carried canine parvovirus, strain CPV‐2b.ConclusionsFecal microbiota transplantation in parvovirus‐infected puppies was associated with faster resolution of diarrhea.
This paper presents a numerical study using the finite element method to assess the structural integrity of welded plates. Different levels of weld misalignment were introduced on the FEM models to investigate the influence of this welding imperfection parameter on the limit state of the structure. The models were loaded under displacement-controlled condition to introduce traction and torsion loads seeking to understand the effects of combined loads on the strain capacity of the misaligned welded structure. Surface elliptical cracks having different crack-size ratios were modeled to study the crack growth behavior by taking into account the misalignment of the weld and combined loads. The damage model is based on a failure surface and post-initiation behavior to model the ductile crack initiation and propagation steps, respectively. The models provide useful information to track the evolution of damage on the hot spot point of the welded structure. The model used is dependent on stress triaxiality and a Lode-based parameter and the damage level is driven by the plastic strain. The evolution of stress triaxiality and Lode parameter with loading are presented, and the influence of misalignment on them are shown. An exponential softening law was adopted to predict post-initiation failure behavior. The calibration steps of the parameters required for damage model application are shown for a A285 pressure vessel steel. Overall, the numerical models reveal the deleterious effects of weld misalignment and combined torsional and tensile loads on the strain capacity of the weld.
This paper presents a numerical study on pipes ductile fracture mechanical response using a phenomenological computational damage model. The damage is controlled by an initiation criterion dependent on the stress triaxiality and the Lode angle parameter, and a post-initiation damage law to eliminate each finite element from the mesh. Experimental tests were carried out to calibrate the elastoplastic response, damage parameters and validate the FEM models. The tested geometries were round bars having smooth and notched cross-section, flat notched specimens under axial tensile loads, and fracture toughness tests in deeply cracked bending specimens SE(B) and compact tension samples C(T). The calibrated numerical procedure was applied to execute a parametric study in pipes with circumferential surface cracks subjected to tensile and internal pressure loads simultaneously. The effects of the variation of geometric parameters and the load applications on the pipes strain capacity were investigated. The influence of longitudinal misalignment between adjacent pipes was also investigated.
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