Medicinal plant raw materials have always been actively used in traditional and folk medicine. This is due to the wide range of medicinal plants therapeutic effect. Due to its therapeutic effect, Mentha asiatica Boriss is widely applied in the Republic of Tajikistan. It is used in the treatment of headaches, respiratory diseases and gastrointestinal tract disorders. To achieve the necessary level of pharmacological effect, it is necessary to take into account that the component composition of biologically active substances can change at different stages of plant development. Therefore, the aim of the study was to determine the component composition of Mentha asiatica essential oil at the stage of budding and flowering. Materials and methods: Samples of the Mentha asiatica essential oil were obtained during budding and flowering to conduct the study by method 1 of the State Pharmacopoeia XIV edition. The chemical composition of Mentha asiatica essential oils was studied by gas-liquid chromatography-mass spectrometry on Agilent 7890 A gas chromatograph with Agilent 5975C mass-selective detector. As a result, components such as limonene, eucalyptol, menthone, pulegone and isopulegone were found in the essential oil of flowering Mentha asiatica. Limonene, caryophyllene, carvone, trans-dihydrocarvone, and beta-bourbonene were found in samples of Mentha asiatica essential oil at the budding stage. It was found that all identified biologically active compounds have a wide range of therapeutic effects. Therefore, detailed studies of the Mentha asiatica essential oils pharmacological activity are of importance.
The article describes the phytochemical studies of Leonuri herba samples, which were harvested in some territories of the Perm Region. The medicinal plant raw materials (MPRM) quality was assessed in relation to such indicators as humidity, total ash, and acid-insoluble ash in accordance with the requirements of the Russian State Pharmacopoeia (XIV edition).
Objective. Determination of the stability of different series of the drug "Piron film-coated tablets, 50 mg", when stored in natural conditions. Materials and methods. Three experimental series of new anti-inflammatory drug Piron tablets were analyzed. The stability study was carried out in accordance with the requirements of the State Pharmacopoeia of the XIV edition, GOST Р 57129-2016 and ICH Q1A: 2003 "Study of the stability of new pharmaceutical substances and drugs." During storage in natural conditions (temperature not higher than 25 ºС, in a dry place protected from light), in accordance with the current regulatory documentation and draft specification all three series of the drug were analyzed by indicators: description, authenticity, mass uniformity, dissolution, dosage uniformity, impurities, microbiological purity, quantitative determination. Results. As a result of stability analysis of the finished dosage form "Piron film-coated tablets, 50 mg", we can conclude that during the storage period in natural conditions (temperature not higher than 25 ºС, in a dry place protected from light) quality parameters met specification requirements. Conclusion. The stability of tablets of the new modern non-steroidal anti-inflammatory drug "Piron film-coated tablets, 50 mg" during storage was investigated and confirmed, when stored under natural conditions. The shelf life is at least two years.
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