Objective: The role of the inanimate environment in the transmission of healthcare-associated infections (HCAIs) is increasingly recognized.Hence, several self-disinfecting surfaces have gained attention as new infection control strategies. The objective of this study was to assess the antimicrobial efficacy of membrane-active polycation (maPK) surfaces against Staphylococcus aureus (S. aureus) applying the in vivo Galleria mellonella (G. mellonella) contamination model.
Methods:In the first set-up maPK surfaces were contaminated with S. aureus and G. mellonella larvae were placed on the surface for 45 min. In the second set-up larvae were contaminated with S. aureus and transferred to maPK surfaces. Finally, the cross-over rates to larvae and maPK-surface were determined. Additionally, log reduction values (LRVs) of S. aureus on contaminated maPK and larvae were calculated.
Results:The first experimental set-up revealed a significantly higher cross-over rate of S. aureus to the larvae from contaminated control surface (~2 x 10 3 colony forming untis (cfu)/mL) when compared to maPK surface (~5.1 x 10 1 cfu/mL).
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.