Background: Peel of a red dragon fruit (Hylocereus Polyrhizus) is rarely utilized which is usually just thrown way, even though it contains such high antioxidants such as phenols, flavonoids and also anthocyanins. Methods: This study aims to determine the effect of red dragon fruit skin extract (Hylocereus Polyrhizus) on MDA levels of lung in rats exposed to cigarette smoke. This research is an experimental study with Post-Test Only Control Group Design. The sample consisted of 30 rats aged 2-3 months which were divided into 5 groups each amounting to 6 rats, namely 1 negative control group was not given exposure to cigarette smoke, 1 group of positive cock was exposed to cigarette smoke, 3 treatment groups were given exposure cigarette smoke and administration of red dragon fruit skin extract with doses of 20mg, 40mh and 80mg for 14 days. The parameters measured were MDA levels of the lung. Results: The mean MDA level of lung control group 1 was 0.146 ± 0.02 nmol / ml, the mean of control group 2 was 0.166 ± 0.01 nmol / ml, the mean of treatment group 1 was 0.168 ± 0.03 nmol / ml, treatment group 2 was 0.153 ± 0.02 nmol / ml, and treatment group 3 was 0.776 ± 0.09 nmol / ml. The significance analysis with the One Way Anova test shows that the value of F = 1.34 and the value of p = 0.282, where the value of p> 0.05 Conclusion: There was no significant difference between the control group and the treatment group or between treatment group 1, treatment 2 and treatment 3.
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