A new efficient procedure has been proposed for the synthesis of 3-aryl-5-amino-1H-pyrazoles by reaction of α-chloro-β-arylacrylonitriles with hydrazine hydrate.
Pyrazole derivatives R 0180New Synthesis of 3-Aryl-5-amino-1H-pyrazoles. -(NENAIDENKO, V. G.; GOLUBINSKII, I. V.; LENKOVA, O. N.; SHASTIN, A. V.; BALENKOVA, E. S.; Russ. J. Org. Chem. 40 (2004) 10, 1518-1520; Dep. Chem., Lomonosov Moscow State Univ., Moscow 119992, Russia; Eng.) -A. Forchert 18-108
The E isomers of α chlorocinnamonitriles react with hydroxylamine to give a mixture of isomeric aminoisoxazoles, while the Z isomers yield 3 aryl 2 chloroacrylamide oximes.
Nitriles
Nitriles Q 0520New Method for the Synthesis of α-Chlorocinnamonitriles. -The reaction of hydrazones with Cl 3 C-CN affords α-chlorocinnamonitriles with marked preponderance of the E-isomer. A convenient one-pot procedure is developed, which allows to prepare α-chlorocinnamonitriles directly from aromatic aldehydes (IV) without isolation of the intermediate hydrazones. -(NENAJDENKO*, V. G.; SHASTIN, A. V.; GOLUBINSKII, I. V.; LENKOVA, O. N.; BALENKOVA, E. S.; Russ.
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