Electromechanical coupling in electroactive polymers (EAPs) has been widely applied for actuation and is also being increasingly investigated for sensing chemical and mechanical stimuli. EAPs are a unique class of materials, with low-moduli high-strain capabilities and the ability to conform to surfaces of different shapes. These features make them attractive for applications such as wearable sensors and interfacing with soft tissues. Here, we review the major types of EAPs and their sensing mechanisms. These are divided into two classes depending on the main type of charge carrier: ionic EAPs (such as conducting polymers and ionic polymer–metal composites) and electronic EAPs (such as dielectric elastomers, liquid-crystal polymers and piezoelectric polymers). This review is intended to serve as an introduction to the mechanisms of these materials and as a first step in material selection for both researchers and designers of flexible/bendable devices, biocompatible sensors or even robotic tactile sensing units.
Magnetic field actuated shape recovery behavior of a 3D box folded by a Nafion/Fe3O4 composite membrane with its surface temperature near body temperature.
Zebrafish exhibit a robust ability to regenerate their hearts following injury, and the immune system plays a key role in this process. We previously showed that delaying macrophage recruitment by clodronate liposome (-1d_CL, macrophage-delayed model) impairs neutrophil resolution and heart regeneration, even when the infiltrating macrophage number was restored within the first-week post injury (Lai et al., 2017). It is thus intriguing to learn the regenerative macrophage property by comparing these late macrophages vs. control macrophages during cardiac repair. Here, we further investigate the mechanistic insights of heart regeneration by comparing the non-regenerative macrophage-delayed model with regenerative controls. Temporal RNAseq analyses revealed that -1d_CL treatment led to disrupted inflammatory resolution, ROS homeostasis, and energy metabolism during cardiac repair. Comparative single-cell RNAseq profiling of inflammatory cells from regenerative vs. non-regenerative hearts further identified heterogeneous macrophages and neutrophils, showing alternative activation and cellular crosstalk leading to neutrophil retention and chronic inflammation. Among macrophages, two residential subpopulations (hbaa+ Mac 2 and timp4.3+ Mac 3) were enriched only in regenerative hearts and barely recovered after -1d_CL treatment. To deplete the resident macrophage without delaying the circulating macrophage recruitment, we established the resident macrophage-deficient model by administrating CL earlier at 8 days (-8d_CL) before cryoinjury. Strikingly, resident macrophage-deficient zebrafish still exhibited defects in revascularization, cardiomyocyte survival, debris clearance, and ECM remodeling/scar resolution without functional compensation from the circulating/monocyte-derived macrophages. Our results characterized the diverse function and interaction between inflammatory cells and identified unique resident macrophages prerequisite for zebrafish heart regeneration.
Electrically deformable surfaces based on dielectric elastomers have recently demonstrated controllable microscale roughness, ease of operation, fast response, and possibilities for programmable control. Potential applications include marine anti-biofouling, dynamic pattern generation, and voltage-controlled smart windows. Most of these systems, however, exhibit limited durability due to irreversible dielectric breakdown. Lowering device voltage to avoid this issue is hindered by an inadequate understanding of the electrically-induced wrinkling deformation as a function of the deformable elastic film thickness. Here we report responsive surfaces that overcome these shortcomings: we achieve fault-tolerant behavior based on the ability to self-insulate breakdown faults, and we enhance fundamental understanding of the system by quantifying the critical field necessary to induce wrinkles in films of different thickness and comparing to analytical models. We also observe new capabilities of these responsive surfaces, such as field amplification near local breakdown sites, which enable actuation and wrinkle pattern formation at lower applied voltages. We demonstrate the wide applicability of our responsive, fault-tolerant films by using our system for adjustable transparency films, tunable diffraction gratings, and a dynamic surface template/factory from which various static micropatterns can be molded on demand.Dynamic control of surface topography and roughness is highly desired for its potential to accomplish what is difficult for traditional static surfaces to achieve, such as adjustable wettability 1 , smart adhesion 2 , antifouling abilities 3 , tunable light diffraction 4 , e-skin and stretchable devices 5,6 . Depending on the material's mechanical properties, such surfaces can show a variety of topographies during deformation, including wrinkling (or buckling), formation of localized ridges, period-doubling, creasing, and delamination 7,8 . Several methods have been used to induce such surface deformation, such as in-plane mechanical compression 9-11 , relaxation after depositing thin films on pre-stretched substrates [12][13][14][15][16][17] , thermal expansion mismatch after cooling thin films deposited on hot substrates [18][19][20][21][22] , ion irradiation 23,24 , differential swelling of film layers 2,[25][26][27][28][29] , and electric-field-induced deformation [30][31][32] . Among these various approaches, electric-field-induced deformation is particularly attractive due to its ability to reversibly actuate at high frequency and its potential for miniaturization and programmable control 33 . This type of deformation relies on the concept of voltage-induced electromechanical instability 34-39 , a phenomenon frequently observed in dielectric elastomer actuators (DEAs) [40][41][42][43][44][45] . Wang and Zhao, for example, have produced creased/cratered/wrinkled structures by immobilizing a DEA on a rigid substrate 32,46 . This DEA-like system is composed of four layers from top to bottom: a conductive li...
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