A 2-month-old infant was admitted for irritability and hypomobility of the left lower limb. Ultrasound revealed a deep hematoma of the iliopsoas muscle and coagulation tests showed increased activated partial thromboplastin time (aPTT). The finding of marked reduction of blood coagulation factor VIII (FVIII) led to the diagnosis of severe Hemophilia A. The infants were promptly put on i.v. factor VIII concentrates, resulting in rapid clinical improvement. As far as known, this is the first documented case of iliopsoas hematoma in such a young infant as early onset of Hemophilia A. Timely diagnosis of hemophilia is crucial to start prompt appropriate treatment, in order to avoid severe bleeding and long-term complications.
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