Our results show that the presence of MOG-abs strongly depends on the age at disease onset and that high MOG-ab titers were associated with a recurrent non-MS disease course.

Vitamin B (12) deficiency can easily be diagnosed by detection of methylmalonic acid when measuring the organic acids in urine. Vitamin B (12) deficiency should be avoided or diagnosed as early as possible since a supplementation of mother and child can prevent neurological symptoms of the baby. Furthermore, the neurological symptoms of the infant with manifest vitamin B (12) deficiency are (partially) reversible.

Zusammenfassung · AbstractMonatsschr Kinderheilkd 2011 · 159:914-917 ZusammenfassungBei der Untersuchung des mental retardierten und stimmungslabilen 16-Jährigen mit kongenitalem Hydrocephalus internus fielen eine parietale Alopezie, eine Hornhauttrübung, ein Brachyturrizephalus, eine spä-te Pubertät, ein Kleinwuchs und eine Ataxie auf. In der Magnetresonanztomographie fanden sich eine Rhombenzephalosynapsis sowie weitere zerebrale Auffälligkeiten. Wir diagnostizierten ein Gómez-López-Hernández-Syndrom. Dieses ist gekennzeichnet durch das kombinierte Auftreten einer Rhombenzephalosynapsis und einer parietalen Alopezie, häufig assoziiert mit weiteren typischen Fehlbildungen. SchlüsselwörterGómez-López-Hernández-Syndrom · Neurokutane Syndrome · Zerebellotrigeminale dermale Dysplasie · Rhombenzephalosynapsis · Alopezie Rhombencephalosynapsis, biparietal alopecia and corneal clouding AbstractThe clinical examination of the mentally retarded and emotionally labile 16-year-old patient with congenital internal hydrocephalus revealed parietal alopecia, slightly clouded corneas, brachyturricephaly, late puberty, short stature and ataxia. Magnetic resonance imaging of the brain showed rhombencephalosynapsis as well as other cerebral abnormalities. We made the diagnosis of Gómez-López-Hernández syndrome. This syndrome is characterized by rhombencephalosynapsis and parietal alopecia, often in association with further typical malformations.

Children and adolescents who had attempted suicide once are at higher risk for further suicide attempts. In order to better identify those likely to make a further suicide attempt, they were compared at the time of their first suicide attempt with those who had only attempted suicide once. The details of all children and adolescents who had attempted suicide and been treated as inpatients or outpatients in the University Hospital in Göttingen, Germany, over a 10-year period were collected by file-analysis. Sociodemographic characteristics, stresses that preceded the suicide attempts and the chosen methods of attempted suicide were ascertained. 55 male und 116 female subjects had attempted suicide once, 17 male and 79 female subjects had attempted suicide more than once. Those with repeated suicide attempts were younger at the time of their first suicide attempt at 14 years and eight months, than those who did not make a repeat attempt, at 15 years and 7 months. Male repeaters more often experienced conflicts with their parents. Female repeaters were suffering more from emotional or chronic physical diseases and more often drank alcohol in connection with their first suicide attempt. Paediatricians, who are often the first to be confronted with suicide attempts by young people, should work towards providing psychotherapeutic support especially for children and younger adolescents with the particular stresses described.

No abstract