Background: In the current proposal, we used the intralipid in standard therapy against COVID / 19 as an energy carrier for parenteral nutrition in critically ill patients. In patients receiving intralipid, there was an accelerated recovery of the lungs, a decrease in markers of endogenous intoxication (EI), tissue hypoxia and an improvement in general condition. In the absence of Intralipid in the intensive care unit, there was a slow recovery of the lungs and a more prolonged improvement in the general condition with the preservation of EI markers (cytolytic enzymes, C-reactive protein, platelets) and tissue hypoxia (pCO2 AV> 6 mm Hg). Collectively, Intralipid has been seen in the targeted LPO treatment plan for oxidative and nitro-galogenic stress in SARS-Cov2 / COVID / 19 patients.
Hibernation proposed by Irving and Krog (1954) was developed by H. Laborit and P. Huguenard, which, today, is very current and important in modern medicine as neurovegetative correction (NVC): Curative anesthesia, neurovegetative blockade, artificial hibernation, capable of providing the minimal metabolic rate at the parabiosis level, and phylogenetic descending cerebral activity. It is important! NVC is not block-free and inhibits excessive impulses, prevents them from attenuating, and installs normal blood pressure, heart rate, body temperature (T°C), blood (pH), adrenal-cholinergic balance, maintaining hibernation homeostasis. From the multiple neurovegetative correction (NVC) schemes of cerebral insufficiency (CI) of various causes (traumas, onco, stroke, neuroinfections, metabolic, hypoxic, etc.), ongoing 35 years, retrospectively, arranged the pattern, with three essential syndromes manifestation of CI: Diencephal -hyperkinetic (catabolic adrenergic), extrapyramidal -eukinetic (balanced), and mezencephal -hypokinetic (anabolic cholinergic). NVC is multimodal and selective inhibition, correction, and analgesia. Thus, by performing the loco-regional correction of the three symptoms of CI and systemic by appropriate medications, NVC can be obtained. Here we describe, diencephal -hyperkinetic syndrome (catabolic adrenergic) → psychic, motor, and vegetative agitation (↑blood pressure [BP], heart rate [HR], T0C) return to normal by administering the usual doses of dexmedetomidine,D with the influence of G-protein and super selective α2-Adreno agonists, as a cerebrospinal locoregional neurotransmitter, D installs anxiolysis, anesthesia, ↓ T0C (central) produces sedation without inhibiting the respiratory center (important in patients with sleep apnea) and central and systemic cerebral effect, α2-Adreno agonist (previously used clonidine) ↓BP, HR, T0C (peripheral), to optimize systemic perfusion pressure, in turn dependent on mean BP and capillary resistance, also stimulates the elimination by endotheliocytes of the NO vasorelaxant → antioxidant, which catches the superoxide O 2 -, at the same time influencing and mitochondrial permeability transition pore dependent Ca++uniporter, mPT pore.
COVID and H3N2 influenza instances are on ascent in India. Both COVID-19 and H3N2 are the infectious viruses. They promulgate through droplets. COVID is transmitted by SARs –Cov2 virus and H3N2 acquired by Influenza A sub type. Contrast to H3N2, COVID 19 cause more serious and symptoms can take longer than flu symptoms. The COVID-19 not only poses a serious threat to the health of people worldwide but also affects the global economy. H3N2 is a variety of influenza virus that has been present among humans since the late 1960s. It is often called the "Hong Kong flu" due to its roots in Asia. Viruses that normally disperse in pigs are “swine influenza viruses". H3N2 is a subtype of the viral genus Influenza Virus A, which is a major cause of current respiratory illness. The H3N2 virus is a non-human influenza virus that normally circulates in pigs and has infected humans with symptoms similar to seasonal flu viruses. Influenza outbreaks have caused widespread illness to humans many times throughout history. In 1968 an avian reasserting virus of the H3N2 subtype was introduced into the human population that caused a global pandemic associated with more than one million deaths world-wide. About half of all inpatient severe acute respiratory infections.H3N2 hospitalized patients suffer from fever, cough, breathlessness and wheezing. Few patients needed oxygen and ICU care. Despite significant advancement in vaccine and virus research, influenza continues to be a major public health concern.
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