Renin-angiotensin system (RAS) plays a central role in pathogenesis of cardiovascular diseases (CVDs) [1]. Its primary biologically active component angiotensin II (Ang II) mediates both direct physiological effects of RAS as vasoconstriction and blood pressure (BP) regulation and pathophysiological ones affecting the function of practically all organs including heart, kidneys, blood vessels, and brain. So, Ang II plays an important role in development of hyperplasia and hypertrophy of smooth muscle cells (SMC) of vessels, hypertrophy and remodelling of myocardium, arterial hypertension (AH), myocardial infarction, atherosclerosis, in-stent restenosis, and renal fibrosis [2,3]. Here, most of AngII pathological effects occur via its interaction with angiotensine II type 1 receptors (AT1R). Traditionally, RAS is considered as circulating hormonal system, however, according to current data, except the circulatory RAS, majority of organs and tissues do also have local, tissue RAS that possess local paracrine and autocrine functions where the tissue RAS components express and function independently of circulatory RAS [4]. In this connection, study of local RAS activity and their contribution into development of CVDs is a research area of current interest. As the expression level of AT1R determines the biological efficiency of Ang II and RAS in whole, study of AT1R density and mechanisms of its regulation poses an especial interest.Objective: assessment and comparing the activity of tissue RAS based on the assessment of level of AT1R expression in SMC of intact and atherosclerotic arteries of patients with multifocal atherosclerosis.
Material and methodsWe investigated 30 resected medium caliber arteries. 16 arteries of patients with low extremity atherosclerosis collected during vascular reconstructive operations made the first study group. The second group consisted of 14 intact mammary arteries collected during coronary bypass Local expression of rennin-angiotensin system (RAS) components significantly increases in patients with arterial hypertension and atherosclerosis with or without elevation of RAS activity in the blood. Our objectives was to assessment and compare the expression level of angiotensin II type 1 receptor in the smooth muscle cells in arteries of patients with multifocal atherosclerosis and the role of local angiotensin II receptor type 1 (At1R) expression in the disease progression. the study results suggest that the tissue RAS activity increases inhomogeneously among patients. It was interestly that At1R expression levels in intact arteries does not differ of those in atherosclerotic arteries. Most of patients had expression of angiotensin II type 1 receptor in smooth muscle of arteries; strong elevation had 43,8% -50,0%. Our study suggest of role of local RAS activity, but we proposed existence of another than only angiotensin II type 1 receptor mechanisms of low or high susceptibility of arteries to atherosclerosis in patient with multifocal atherosclerosis.
Russ
ANGIOTENSIN II RECEPTOR TYPE ...
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.