Efficient Synthesis of Isoxazolidine-Substituted Bisphosphonates by 1,3-Dipolar Cycloaddition Reactions. -Several bisphosphonate esters (III) bearing a substituted isoxazolidine moiety are synthesized in the absence of any solvent in good yields and short reaction times. They can be further converted into the corresponding bisphosphonic acids by subsequent hydrolysis. Disodium salts are isolated after treatment with aqueous NaOH to be used as calcium-regulating agents. -(BORTOLINI*, O.; MULANI, I.; DE NINO, A.; MAIUOLO, L.; NARDI, M.; RUSSO, B.; AVNET, S.; Tetrahedron 67 (2011) 31, 5635-5641, http://dx.
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