A study evaluating zinc supplementation in patients with Alzheimer's disease yielded variable zinc plasma levels in spite of positive cognitive and physiological results. In an attempt to raise and sustain plasma zinc levels, a single patient was given 15 mg zinc/day with various combinations of vitamins. A sustained raise in plasma zinc concentration (and therefore its potential bioavailability) was obtained only when the zinc was augmented with both vitamins A and D (in RDA concentrations). In order to verify these results, a follow-up study was conducted in 70 volunteers. Seven groups of 10 healthy subjects received various combinations of zinc and the two vitamins A and D, namely: zinc, vitamin A, vitamin D, zinc plus vitamin A, zinc plus vitamin D, vitamins A and D, and zinc plus vitamins A and D. Plasma zinc levels were determined at baseline, 3 weeks and 6 weeks. Plasma zinc levels increased significantly (p < 0.02) from 11.82 (+/-2.60) to 13.32 (+/-3.04) mum/L only in the group receiving the combination of zinc and vitamins A and D. This novel method of increasing plasma zinc levels by the augmentation of vitamins A and D may have implications for the reduction of burden of disease.
A general route to the di(thieny1thio)thiophens has been developed. Four isomers (I-IV) have been prepared by condensation of thiophen 2-or 3-thiol with 2,5-or 3,4-dibromothiophen in the presence of cuprous oxide in dimethylformamide. These compounds may be oxidised using hydrogen peroxide to the corresponding sulphones.RECENTLY we reported the synthesis of the isomeric dithienyl sulphides by condensation of a thiophen thiol with a halogenothiophen promoted by cuprous oxide in dimethyl-f0rmamide.l We have now extended this work to the preparation of four of the isomeric di(thieny1thio) thiophens ( 1)-(IV). Of these isomers only 2,5-di-(Z-thienylthio)thiophen
A method for fish species identification by agarose gel isoelectric focusing was collaboratively studied to determine if unknown samples could be identified by comparison of the unknown protein pattern with a photograph of protein patterns from authentic species. Fourteen collaborators were sent 19 or 20 unknown samples along with supplies and instructions for making pH 2.5-9.0 agarose isoelectric focusing gels. The unknown sarcoplasmic protein patterns were identified by comparison with a supplied 8 X 10 in. photograph of protein patterns from 18 authentic species. The 14 collaborators identified a total of 276 unknown samples with 84% accuracy. Eight of 14 collaborators averaged 90% or more correct. Two collaborators averaged 80-85% correct, while the remaining 4 collaborators averaged 50-69% correct. No one species was consistently misidentified; however, the method is not recommended for adoption in its present form.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.