Ayurvedic system of medicine is well known for treating renal problems. A vast number of medicinal plants mentioned in Ayurvedic system of medicine are known to possess diuretic properties. Present study reports the preliminary phytochemical investigation of petroleum ether and ethanolic extracts of Cyclea peltata and their diuretic activity. Preliminary phytochemical screening reveals the presence of phytosterols and alkaloids as major phytoconstituents in petroleum ether extract. The ethanolic extract showed the presence of alkaloids, flavonoids, tannins, diterpenes and saponins. Pharmacological investigation revealed that ethanolic extract of C. peltata leaves possessed significant diuretic activity in a given dose of 200 and 300 mg/kg body weight (Diuretic action 1.7 and 2.6, respectively). Where as petroleum ether extract has shown moderate diuresis at a dose of 300 mg/kg body weight (Diuretic action 1.1). The present study justifies the use of C. peltata in the Ayurvedic system of medicine as a diuretic drug.
Paracalyx scariosa (Roxb.) Ali. is a woody twiners belongs to the family Fabaceae. The use of plant has been mentioned in folk medicine to treat liver disorders. The review has been reported the presence of flavonoids like quercetin, rutin and kaempferol etc. There are scientific proofs available regarding the hepatoprotective effect of these flavonoids. However, no scientific record is available for the hepatoprotective activity of Paracalyx scariosa (Roxb.) Ali. Hence the present study was designed to evaluate the protective activity of Paracalyx scariosa (Roxb.) Ali against ethanol induced toxicity. Protective effect of extracts (methanol, benzene and acetone) and fractions (ethyl acetate, aqueous) of methanol was tested against ethanol induced toxicity in BRL 3A cell lines. The degree of hepatoprotection was determined by measuring cell viability, cytotoxicity marker LDH and hepatic marker enzymes AST, ALT and ALP. Silymarin was used as the standard drug for comparison. The extracts and fractions significantly reduced the ethanol induced cytotoxicity and elevated the reduced levels of LDH, AST, ALT, and ALP after treatment. The results were analyzed by one way ANOVA followed by Dunnett's test. The present study suggests that the extracts (methanol, benzene and acetone) and fractions (ethyl acetate, aqueous) of Paracalyx scariosa (Roxb.) Ali. possess significant hepatoprotective activity which was found to be dose dependent in BRL 3A cell lines.
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