Capecitabine is used to treat advanced breast and gastrointestinal malignancies. A single case of encephalopathy and three cases of peripheral neuropathy are the only neurotoxicities reported. The authors report five additional cases of capecitabine-induced multifocal leukoencephalopathy.
A stereotypic angiospasm develops in intraorganic arteries during coarctation of the aorta, which is characterized by different functional impacts: resistance in the basin of elevated vascular pressure and pressure and bloodflow regulation in the hypotension basin. The most marked structural changes are observed in the renal and coronary arteries. Changes in the small coronary arteries are mainly due to myocardial hypertrophy, whereas in the larger ones they are caused by the increased pressure transferred from the aorta. The degree of structural changes in the larger coronary arteries is greater than in the small arteries.
The purpose of the research is to find additional diagnostic tools that allow you to specify the nature of soft tissue lesions, differentiate between benign and malignant processes this localization.Materials and methods. Using multiparametric echography surveyed 514 patients with malignant (243 or 55.7%) and benign (193 or 44.3%) tumor, as well as non-tumor (78 or 15.2%) diseases. In all cases, used while rendering, color Doppler mapping, power Doppler blood flow spectral characteristics of the studied zone changes. In 87 (16.9%) observations applied functional vascular test.The results. Calculation of indicators diagnostic informative at diagnostics of sarcomas in relation to complex high without the use of vascular test and when you post data showed an increase in using it specificity and diagnostic accuracy stability in the total sensitivity of the entire complex. Sensitivity respectively amounted to 92.7% and 92.7%, specificity – 87.1% and 98.9%, accuracy-84.8% and 91.1% (inclusion in consideration of inflammatory processes led to the authenticity of the results obtained).Conclusion. Vascular test improves diagnostic high informativeness of the complex, but it can be usefully applied to exclude non-tumorous changes and accounting possible differences in differentiation of different constituent parts neoplasm.
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