We compared the expression of signal molecules in the culture of human endothelial cells under normal conditions and in atherosclerosis and restenosis. Expression of connexin-37 and sirtuin-1 in atherosclerosis and restenosis surpassed the normal by 2 and 5 times, respectively, and expression of endothelin-1 3-fold surpassed the normal. In restenosis, changes in the expression connexin-37 and endothelin-1 became more pronounced in comparison with atherosclerosis. Connexin-37 and endothelin-1 can serve as predictive markers for prognosis of post-stenting complications in patients with atherosclerosis.
И.И. Болотов Влияние пептида KED на экспрессию коннексина и сиртуина при атеросклерозе и рестенозе у людей пожилого возраста Автономная научная некоммерческая организация высшего образования научноисследовательский центр «Санкт-Петербургский институт биорегуляции и геронтологии», пр. Динамо, д. 23, г. Санкт-Петербург, 197110, Российская Федерация Автор для переписки: И.И. Болотов
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