It wus previously repurted by us tnat, in animals infected witll herpes airuplex viruP typ~ I in a 4-lo day acute experimel!t, virus autiL,en und antibodies could be detected in the Glomeruli. In the prcaent chronic «xperi .. ,u,,t, 11 New Zealand rabbi ts were infecteai.v. with herpes simplex virus type I for 8 weeks. lo aniillals served as controls.After 8 weeks, kid1Jey,hrain,blood and urine exa,11im,tions were performed. The quantity of soluble im,,,une co,nplex vulue wus rneasured in 6 of the 11 ani1.,ul:, anrt a 1,1od,•rately patholoc;ic value in J. In 9 rabbi ts virus a,1tir;e!: and granular le;U v1ere detected on the t;lorn,rular basal mer,;brane, and lighti,,icroscopic ex£rni1:ation co!lfirrned 1. esanc;ial proliferative t_;loroerulonephri tis in all 9. lndependently of the renal virus titre, viruriu was found in 8 cases.