Background: Syphilis is one of the most common sexually transmitted infections every year. In mothers who do not receive treatment, transmission of infection from mother to fetus can occur, causing congenital syphilis. The purpose of this study was to describe the characteristics of cases of congenital syphilis in Wangaya Hospital, Denpasar. Methods: This descriptive study used the medical records of pediatric patients at the Wangaya Hospital, Denpasar, for the period January 2020 to October 2021. The inclusion criteria used were newborns diagnosed with congenital syphilis with complete medical record data. The exclusion criteria used were newborns suffering from congenital syphilis accompanied by other infections, namely Toxoplasma gondii, rubella, cytomegalovirus, herpes simplex, and other congenital disorders not related to syphilis. Results: Of the 47 study subjects who met the inclusion criteria, 68.1% of cases were asymptomatic and 31.9% symptomatic, 68.1% of term pregnancy, 31.9% preterm, low birth weight 29.8%, very low 4 .3%, and 66% normal body weight. Clinical manifestations found in symptomatic cases were respiratory distress (27.7%), jaundice/jaundice (21.3%), anemia (19.1%), skin lesions/rash (12.8%), sepsis (10 .6%), leukocytosis (10.6%), and thrombocytopenia (10.6%). Outcome of survival was 93.6% and death was 6.4% of cases. Conclusion: Most cases of congenital syphilis are asymptomatic. In symptomatic cases, the characteristic clinical manifestations that are often encountered are respiratory distress, jaundice, anemia, skin rash, sepsis, leukocytosis, and thrombocytopenia. Recognizing the characteristics of congenital syphilis cases early is very important to reduce mortality from the disease. Latar Belakang: Sifilis merupakan salah satu infeksi menular seksual yang banyak terjadi setiap tahunnya. Pada ibu yang tidak mendapatkan pengobatan, dapat terjadi transmisi infeksi ibu ke janin sehingga menyebabkan kejadian sifilis kongenital. Tujuan penelitian ini adalah untuk mengetahui gambaran karakteristik dari kasus-kasus sifilis kongenital di RSUD Wangaya kota Denpasar. Metode: Penelitian deskriptif ini menggunakan rekam medis pasien anak di RSUD Wangaya kota Denpasar periode Januari 2020 hingga Oktober 2021. Kriteria inklusi yang digunakan adalah bayi baru lahir yang didiagnosis sifilis kongenital dengan data rekam medis yang lengkap. Kriteria eksklusi yang digunakan adalah bayi baru lahir yang menderita sifilis kongenital disertai infeksi lainnya, yaitu Toxoplasma gondii, rubella, cytomegalovirus, herpes simplex, maupun kelainan kongenital lain yang tidak berkaitan dengan sifilis. Hasil : Dari 47 subjek penelitian yang masuk di dalam kriteria inklusi, 68,1% kasus asimptomatik dan 31,9% simptomatik, kehamilan aterm 68,1%, kurang bulan 31,9%, berat badan lahir rendah 29,8%, sangat rendah 4,3%, dan berat badan normal 66%. Manifestasi klinis yang ditemukan pada kasus simptomatik, yaitu distres nafas (27,7%), ikterus/jaundice (21,3%), anemia (19,1%), lesi/ruam kulit (12,8%), sepsis (10,6%), leukositosis (10,6%), dan trombositopenia (10,6%). Luaran hidup 93,6% dan meninggal 6,4% kasus. Kesimpulan : Sebagian besar kasus sifilis kongenital tidak bergejala atau asimptomatik. Pada kasus bergejala, karakteristik manifestasi klinis yang sering ditemui adalah distres nafas, jaundice, anemia, ruam kulit, sepsis, leukositosis, dan trombositopenia. Mengenali karakteristik kasus sifilis kongenital sejak dini sangat penting untuk mengurangi mortalitas dari penyakit.
Background: Sepsis is still a serious world health threat, especially in developing countries, including Indonesia. Blood culture examination as the gold standard for diagnosis has several drawbacks, thus encouraging clinicians to find new markers with shorter examination times and affordable costs. This study examines the relationship between RNL, MPV and RDW with early-onset neonatal sepsis (EONS) at Wangaya Hospital, Denpasar City. Methods: This cross-sectional analytic observational study using the consecutive sampling method was carried out by collecting medical record data for neonates at risk for neonatal sepsis who were treated at the Wangaya Hospital, Denpasar City from January 2020 to September 2021. The cut off values for RNL, MPV and RDW were determined using a receiver-operating characteristic curve. (ROC). Chi-square analysis and multivariate logistic regression were performed to determine the significant relationship. Results: Of the 110 sample subjects, 57 subjects (47.5%) had a diagnosis of SNAD. The results of bivariate analysis, RNL with a cut off value of 2.23 (p<0.001), MPV with a cut off value of 9.95 fL (p<0.001), and RDW with a cut off value of 16.15% (p<0.001) were associated with EONS. The results of multivariate analysis showed that RNL (OR=3.32, p=0.012), MPV (OR=3.83, p=0.004), and RDW (OR=3.47, p=0.006) were the single predictors of EONS. Conclusion: neutrophil lymphocyte ratio (RNL), red cell distribution width (RDW), mean platelet volume (MPV) as independent predictor of early-onset neonatal sepsis (SNAD). Latar Belakang: Sepsis saat ini masih merupakan ancaman kesehatan dunia yang serius, terutama di negara berkembang, termasuk Indonesia. Pemeriksaan kultur darah sebagai baku emas diagnosis memiliki beberapa kelemahan, sehingga mendorong klinisi untuk menemukan penanda baru dengan waktu pemeriksaan lebih singkat dan biaya terjangkau. Studi ini meneliti hubungan RNL, MPV serta RDW dengan sepsis neonatorum awitan dini (SNAD) di RSUD Wangaya, Kota Denpasar. Metode: Penelitian observasional analitik potong lintang ini menggunakan metode consecutive sampling dilakukan dengan mengumpulkan data rekam medis neonatus dengan resiko sepsis neonatorum yang dirawat di RSUD Wangaya Kota Denpasar dari Januari 2020 hingga September 2021. Nilai cut off RNL, MPV dan RDW ditentutkan menggunakan kurva receiver-operating characteristic (ROC). Analisis chi-square dan regresi logistik multivariat dilakukan untuk mengetahui hubungan yang bermakna. Hasil: Dari 110 subjek sampel, sebesar 57 subjek (47,5%) dengan diagnosis SNAD. Hasil analisis bivariat, RNL dengan nilai cut off 2.23 (p<0,001), MPV dengan nilai cut off 9,95 fL (p<0,001), serta RDW dengan nilai cut off 16,15% (p<0,001) berhubungan dengan SNAD. Hasil analisis multivariat, menunjukkan RNL (OR=3,32, p=0,012), MPV (OR=3,83, p=0,004), serta RDW (OR=3,47, p=0,006) merupakan prediktor tunggal kejadian SNAD. Simpulan: rasio neutrofil limfosit (RNL), red cell distribution width (RDW), mean platelet volume (MPV) sebagai prediktor tunggal sepsis neonatorum awitan dini (SNAD).
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