Bacteria causing chronic infection was P aeruginosa in BC (n=7;100%), and in LT, P aeruginosa (n=6; 75%) and Proteus mirabilis (n=2; 25%). AZLI treatment duration was 20.6±14.2 months (BC) and 10.1±9.7 months (LT). Respiratory function tests during AZLI (mean values of the population) are shown in table 1. Comparing BC with LT, a statistically significant improvement was observed in FVC (p=0.011) and FEF25-75 (p=0.005) but this was not clinically relevant. BC annual emergency admissions were 0.07 before and 0.42 during AZLI; annual rates of hospital admissions were 0.44 and 0.55, respectively. Remission data (negative results in sputum burdens) were: BC (n=2, 28.6%) and LT (n=1, 12.5%). The most commonly reported treatment emergent adverse effects (AE) were dyspnoea, bronchospasm and arthralgias in BC (n=3; 42,9%). There were no AE in LT and no deaths in either group. Conclusion and relevance The results suggest that off-label use of AZLI in complicated chronic infected patients could control gram negative infection and neutralise sputum burdens in some cases, while maintaining lung function and decreasing accelerated clinical deterioration. REFERENCES AND/OR ACKNOWLEDGEMENTS No conflict of interest.
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