After the intraperitoneal administration of 86RbCl to mice in a dose of 0.5 mM/kg, the maximum levels in the liver and kidneys were attained in the first hour, but in the brain not for 24 h. The Rb+ half-time in the tissues was about 170 h. With peroral administration, tissue rubidium levels at 3 days were higher than after intraperitoneal injec-tion. Rubidium did not affect sodium levels in rats, but lowered potassium levels. Cesium led to an increase in tissue rubidium levels, while diuretics had not significant effect on them. The erythrocyte saturation rate was correlated to the species, but there were no differences between young and old individuals, or between healthy subjects and manic-depressive patients. Rubidium was not displaced from the erythrocytes by the presence of high potassium concentrations in the medium.
After the intraperitoneal administration of 0.5 mEq 134CsCl • kg^-1 to mice,
the maximum cesium level in the kidneys, heart, lungs and liver was found in the first hour
(T(1/2) 13 h), in the muscles after 8 h (T(1/2) 180 h), in the brain after 24 h (T(1/2) 140 h) and in
the blood after 24 h. Maximum cesium levels were found in the muscles. Rats excreted about
17% of the administered dose in 24 h and 38% in 144 h. Most of the cesium (about 90%) is
excreted in the urine. In rats, equalization of the plasma and RBC cesium levels takes longer
than 6 h. Cesium transport is not entirely dependent on the ATPase system, as shown by the
results given by the crude mitochondrial fraction with a reduced potassium content. Among
the various univalent ions studied, the effect of cesium on creatine kinase, 5'-nucleotidase,
phosphodiesterase and deaminase activity was the smallest.
The authors studied the effect of rubidium, lithium and cesium on the ATPase system and c-AMP protein kinase in brain. They demonstrated that rubidium could replace potassium in the Na+K+-ATPase system, whereas lithium and cesium had no effect on this enzyme activity in the absence of potassium. K+-dependent ATPase was activated by even low rubidium concentrations; lithium and cesium inhibited it. None of three (rubidium, lithium and cesium) affected c-AMP protein kinase.
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