Donor blood serum was tested to detect antibodies against circulating influenza viruses. The titer of specific antibodies was determined in the hemagglutination inhibition test (RTGA) against influenza viruses A/California/07/09(H1N1) pdm09, A/HongKong/4801/14(H3N2) and B/Brisben/46/15. In the pre-epidemic period 2018–2019, the immune layer of people with conditionally protective titers of antiviral antibodies was detected in terms of the lowest to A(H3N2) virus (50.0 %), the highest to influenza B (85.4 %). In the post-epidemic season of 2018–2019, the immune layer to influenza A(H1N1) pdm09 virus did not change significantly, which could indicate the preservation of the activity of this virus in the adult population; an increase in the immune layer of individuals with protective titers of antibodies to influenza A(H3N2) – 67.4 % and a decrease in influenza B virus – 49.2 %. A comparison of the results of laboratory data carried out in the pre- and post-epidemic seasons revealed significant differences in the number of people with average antibody titers against influenza A(H3N2) and B viruses (p < 0.05).
On March 11, 2020, WHO stated a pandemic of coronavirus infection caused by the SARS-CoV‑2 virus with an aerogenic mechanism of transmission of the pathogen. With epidemic increases in the incidence of influenza and SARS registered annually in the world, the involvement of a new coronavirus in the epidemic process may exacerbate the situation. In the presented work, an assessment of the epidemiological situation of influenza in the Sverdlovsk region is given. Studies have shown that the excess of the epidemic threshold and the increase in the total incidence of respiratory infections can be explained by the presence of laboratory-confirmed cases of COVID‑19 in mild form. The epidemic process mainly involved the older age group of the population (15+ years). In the last epidseason, influenza A(H1N 1) pdm09 and A(H3N 2) viruses stopped circulating, and influenza B virus accounted for only 0.2 %.
Dissemination of infectious inflammation was studied in experimental influenza and acute and chronic herpesvirus infections. The possibility of articular involvement into the infectious process was evaluated. Pathomorphological signs of changes in the articular tissue confirmed the effects of these viruses on the locomotor pathology. Results of virus infection simulation in experimental animals suggest this model for studies of the pathogenesis of diseases of viral etiology (including those with articular involvement) in humans.
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