A modifying influence of ortho-cresol (o-cresol) on the carcinogenic effect of benzo(a)pyrene (BaP) with combined oral administration to CC57Br mice had been found. During simultaneous administration of o-cresol (1 mg) and BaP (1 mg), the incidence of tumors, the multiplicity of tumors, and the degree of malignancy all increased, but the latency was shortened. When o-cresol was administered before or after BaP (in identical doses), the carcinogenic effect was weakened. When o-cresol (10 mg) and BaP (5 mg) were administered simultaneously, the incidence of malignant tumors was similar to controls receiving BaP only (13.8%), indicating inhibition of carcinogenesis.
In the modern world in different spheres of life, people experience a load of the complex of numerous chemical compounds of different types, which have a wide range of biological effects - from toxic ones to mutagenic and carcinogenic. For instance, people suffer from the growth of cancer, which is one of the direct consequences of the impact of environmental pollution by chemical compounds. It has now been proved that the development of cancer is determined not only by the initiating effect of chemical carcinogens, but also by the modifying effect of the concomitant toxic compounds. The aim of this work was experimental study of the role of toxic substances (phenol) in the modification of the evidence of genotoxic and immunological changes in organism in the early stages of carcinogenic activity (benzo[a]pyrene).The studies were conducted with random-bred white male mice. Peroral administration was applied to animals taken benzo[a]pyrene (day-dose 0.1mg), benzo[a]pyrene - phenol (day-dose 0.1; 0.002 mg). Genotoxic changes in forestomach were assessed with the help of micronuclear test. The carcinogenic effect (forestomach papillomas) and common regularities of genotoxical and immunological changes in relation to carcinogenesis and their dose and treatment duration dependence under benzo[a]pyrene (day-dose 0,1mg), benzo[a]pyrene and phenol (day-dose 0,1; 0,002 mg) complexes oral administration in random-bred white mice were established. The noted regularities conducted in interrelation and identical directivity of mutagenic (increasing of micronucleus incidence) and immunological (reducing the relative number of T-lymphocytes) indexes changes in relation to carcinogenesis, presence of reliable cross-correlation connections between them in the end of the first months. Besides, the modifying effect of phenol on the carcinogenesis that appeared by increasing of micronucleus incidence, immunosuppression and index of forestomach papillomas multiplicity was determined. The findings detect the presence of cancer risk from the action of carcinogenic and toxic substances, the formation of which begins in the early period (at the end of the first month) and manifests itself as a genotoxic effect in combination with immunosuppression, which must be taken into account in the hygienic assessment of the state of the environment. Citation Format: Olga Ostash, Igor Chernichenko, Nina Balenko, Elena Vinarska, Lyudmila Grigorenko, Svetlana Lukyanchuk, Oksana Shvager. Phenol modifying influence on genotoxic effect in organism during peroral combined administration with benzo[a]pyrene [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2018; 2018 Apr 14-18; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2018;78(13 Suppl):Abstract nr 3090.
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