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The FFC is a more realistic and preferred model for direct laryngoscopic orotracheal intubation training. Trucorp and Laerdal manikin can be used as alternative models.

The Korean VLBI Network (KVN) is a new mm-VLBI dedicated array with capability for simultaneous observations at multiple frequencies, up to 129 GHz.The innovative multi-channel receivers present significant benefits for astrometric measurements in the frequency domain. The aim of this work is to verify the astrometric performance of the KVN using a comparative study with the VLBA, a well established instrument. For that purpose, we carried out nearly contemporaneous observations with the KVN and the VLBA, at 14/7 mm, in April 2013. The KVN observations consisted of simultaneous dual frequency observations, while the VLBA used fast frequency switching observations. We used the Source Frequency Phase Referencing technique for the observational and analysis strategy. We find that having simultaneous observations results in a superior performance for compensation of all atmospheric terms in the observables, in addition to offering other significant benefits for astrometric analysis.We have compared the KVN astrometry measurements to those from the VLBA.We find that the structure blending effects introduce dominant systematic astrometric shifts and these need to be taken into account. We have tested multiple analytical routes to characterize the impact of the low resolution effects for extended sources in the astrometric measurements. The results from the analysis of KVN and full VLBA datasets agree within 2-σ of the thermal error estimate.We interpret the discrepancy as arising from the different resolutions. We find that the KVN provides astrometric results with excellent agreement, within 1-σ, when compared to a VLBA configuration which has a similar resolution. Therefore this comparative study verifies the astrometric performance of KVN using SFPR at 14/7 mm, and validates the KVN as an astrometric instrument. Subject headings: Astrometry -techniques: interferometric -quasars: individual (OJ287, 0854+213)GHz, along with KVN observations using a similar configuration, both carried out in April 2013. The VLBA observations were carried out using fast frequency switching between both bands, while the KVN used simultaneous dual frequency observations. This study will serve to deepen the understanding on the limitations imposed by the fast frequency switching observing mode (i.e. with the VLBA), and the benefits derived from simultaneous dual frequency simultaneous observations with the multi-channel receivers in the KVN. The driver for this is to investigate whether to equip global baselines with KVN-like systems or more conventional fast frequency-switching systems.The interest and basis of the SFPR method have been described in detail in other publications ; most recently, the application to spectral line observations of H 2 O and SiO masers in evolved stars, with a non integer frequency ratio, is presented in Dodson et al. (2014). In summary, the SFPR technique provides at mm-wavelengths the benefits that conventional PR has in the cm-wavelength regime, where the moderate tropospheric phase fluctuations can be match...

Gastric cancer (GC) is a leading cause of death. We aim to establish a clinically relevant assay that encompasses recent molecular classifications and provides useful clinical information in a large cohort of GC patients. A consecutive series of 438 GC patients that underwent palliative chemotherapy between 2014 and 2015 were assessed using 10 GC panels: EBER in-situ hybridization, immunohistochemistry for mismatch repair (MMR) proteins (MLH1, PMS2, MSH2, and MSH6), receptor tyrosine kinases (RTKs; HER2, EGFR, and MET), PTEN, and p53 protein. With a median of one aberration, 3.3 % of samples analyzed were Epstein-Barr virus (EBV)-positive; 4.8%, MMR-deficient. RTKs were overexpressed in 218 patients; EGFR was most commonly overexpressed (39.9%), followed by HER2 (13.5%) and MET (12.1%). Furthermore, 2.5 % and 10.7 % of cases had simultaneous overexpression of three and two RTKs, respectively. p53 overexpression/null tumors were identified in 259 patients (59.1%), and PTEN loss was identified in 89 patients (20.3%). EBV-positivity was mutually exclusive with MMR-deficiency, predominantly identified in male patients, and these tumors were undifferentiated with proximal location. p53 mutant type was significantly found predominantly in the EBV-negative (60.6% vs 14.3%, P=0.001) and HER2-positive (78.0% vs 56.2%, P=0.002) groups. We described a molecular spectrum of distinct GC subtypes using clinically applicable assay. This assay will provide a convenient screening tool and facilitate the development of targeted agents in clinical trials.

Oxygen-rich Asymptotic Giant Branch (AGB) stars can be intense emitters of SiO (v=1 and 2, J=1→0) and H 2 O maser lines at 43 and 22 GHz, respectively. VLBI observations of the maser emission provide a unique tool to probe the innermost layers of the circumstellar envelopes in AGB stars. Nevertheless, the difficulties in achieving astrometrically aligned H 2 O and v=1 and v=2 SiO maser maps have traditionally limited the physical constraints that can be placed on the SiO maser pumping mechanism. We present phase referenced simultaneous spectral-line VLBI images for the SiO v=1 and v=2, J=1→0, and H 2 O maser emission around the AGB star R LMi, obtained from the Korean VLBI Network (KVN). The simultaneous multi-channel receivers of the KVN offer great possibilities for astrometry in the frequency domain. With this facility we have produced images with bona-fide absolute astrometric registration between high frequency maser transitions of different species to provide the positions of the H 2 O maser emission, and the centre of the SiO maser emission, and hence reducing the uncertainty in the proper motion for R LMi by an order of magnitude over that from Hipparcos. This is the first successful demonstration of source frequency phase referencing for mm-VLBI spectral-line observations and also where the ratio between the frequencies is not an integer.

The Korean very-long-baseline interferometry (VLBI) network (KVN) and VLBI Exploration of Radio Astrometry (VERA) Array (KaVA) is the first international VLBI array dedicated to high-frequency (23–43 GHz bands) observations in East Asia. Here, we report the first imaging observations of three bright active galactic nuclei (AGNs) known for their complex morphologies: 4C 39.25, 3C 273, and M 87. This is one of the initial results of KaVA's early operation. Our KaVA images reveal extended outflows with complex substructures such as knots and limb brightening, in agreement with previous Very Long Baseline Array (VLBA) observations. Angular resolutions are better than 1.4 and 0.8 mas at 23 and 43 GHz, respectively. KaVA achieves a high dynamic range of ∼ 1000, more than three times the value achieved by VERA. We conclude that KaVA is a powerful array with a great potential for the study of AGN outflows, at least comparable to the best existing radio interferometric arrays.

We report simultaneous multi-frequency observing performance at 22 and 43 GHz of the 21-m shaped-Cassegrain radio telescopes of the Korean VLBI Network (KVN). KVN is the first millimeter-dedicated VLBI network in Korea having a maximum baseline length of 480 km. It currently operates at 22 and 43 GHz and planed to operate in four frequency bands, 22, 43, 86, and 129 GHz. The unique quasioptics of KVN enable simultaneous multi-frequency observations based on efficient beam filtering and accuarate antenna-beam alignment at 22 and 43 GHz. We found that the offset of the beams is within < 5 arcseconds over all pointing directions of antenna. The dual polarization, cooled HEMT receivers at 22 and 43 GHz result in receiver noise temperatures less than 40 K at 21.

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