Hyunsil Ko scite author profile

Hyunsil Ko

4Publications

94Citation Statements Received

23Citation Statements Given

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Affiliations

Seoul National University, Kunsan National University, Korea Institute of Science and Technology

Publications

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Scalarane Sesterterpenes from a Marine Sponge of the Genus Spongia and Their FXR Antagonistic Activity

Nam

et al. 2007

J. Nat. Prod.

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Three new scalarane-based sesterterpenes, 1- 3, were isolated from a marine sponge of the genus Spongia, and their chemical structures were elucidated by analysis of HRMS and 2-D NMR spectra. The isolated compounds 1 and 3 showed inhibition against the farnesoid X-activated receptor (FXR) with IC50 values of 2.4 and 24 microM, respectively. In particular, compound 3 directly inhibited the interaction between FXR and a coactivator peptide (SRC-1) as determined by surface plasmon resonance (SPR) spectroscopy.

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Farnesoid X-activated receptor antagonists from a marine sponge Spongia sp.

Nam

Shin

et al. 2006

Bioorganic & Medicinal Chemistry Letters

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Farnesoid X‐Activated Receptor Antagonists from a Marine Sponge Spongia sp.

Nam

Shin

et al. 2007

ChemInform

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Selective peroxisome proliferator-activated receptor δ isosteric selenium agonists as potent anti-atherogenic agents in vivo

Chin¹,

Hong²,

Lee³

et al. 2010

Bioorganic & Medicinal Chemistry Letters

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Hyunsil Ko

Scalarane Sesterterpenes from a Marine Sponge of the Genus Spongia and Their FXR Antagonistic Activity

Farnesoid X-activated receptor antagonists from a marine sponge Spongia sp.

Farnesoid X‐Activated Receptor Antagonists from a Marine Sponge Spongia sp.

Selective peroxisome proliferator-activated receptor δ isosteric selenium agonists as potent anti-atherogenic agents in vivo

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