This paper presents a novel structure-preserving image decomposition operator called bilateral texture filter. As a simple modification of the original bilateral filter [Tomasi and Manduchi 1998], it performs local patch-based analysis of texture features and incorporates its results into the range filter kernel. The central idea to ensure proper texture/structure separation is based on patch shift that captures the texture information from the most representative texture patch clear of prominent structure edges. Our method outperforms the original bilateral filter in removing texture while preserving main image structures, at the cost of some added computation. It inherits well-known advantages of the bilateral filter, such as simplicity, local nature, ease of implementation, scalability, and adaptability to other application scenarios.
Man-made structures often appear to be distorted in photos captured by casual photographers, as the scene layout often conflicts with how it is expected by human perception. In this paper, we propose an automatic approach for straightening up slanted man-made structures in an input image to improve its perceptual quality. We call this type of correction upright adjustment. We propose a set of criteria for upright adjustment based on human perception studies, and develop an optimization framework which yields an optimal homography for adjustment. We also develop a new optimization-based camera calibration method that performs favorably to previous methods and allows the proposed system to work reliably for a wide range of images. The effectiveness of our system is demonstrated by both quantitative comparisons and qualitative user study.
Problematic alcohol use (PAU) is a leading cause of death and disability worldwide. To improve our understanding of the genetics of PAU, we conducted a large cross-ancestry meta-analysis of PAU in 1,079,947 individuals. We observed a high degree of cross-ancestral similarity in the genetic architecture of PAU and identified 110 independent risk variants in within- and cross-ancestry analyses. Cross-ancestry fine-mapping improved the identification of likely causal variants. Prioritizing genes through gene expression and/or chromatin interaction in brain tissues identified multiple genes associated with PAU. We identified existing medications for potential pharmacological studies by drug repurposing analysis. Cross-ancestry polygenic risk scores (PRS) showed better performance in independent sample than single-ancestry PRS. Genetic correlations between PAU and other traits were observed in multiple ancestries, with other substance use traits having the highest correlations. The analysis of diverse ancestries contributed significantly to the findings, and fills an important gap in the literature.
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