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likelihood of causality of observed associations (Sassolas et al., 2010). Results from a sensitivity analysis in which we shifted the index date to 2 weeks before the date of the first recorded SJS/TEN diagnosis in all patients without recorded prodromal symptoms were virtually unchanged (see Supplementary Table S3). Further strengths and limitations of our study population and data source have been discussed elsewhere (Frey et al. 2017a, 2017b). In summary, our results suggest that the previously reported association between cotrimoxazole and SJS/TEN is at least partly attributable to the nonsulfonamide antibiotic trimethoprim, which is frequently given in combination with sulfamethoxazole. Our study further corroborates previously reported associations between SJS/TEN and penicillins, quinolones, cephalosporins, and macrolides.