Background and objectives: Cytokine thymic stromal lymphopoietin (TSLP) plays a pivotal role in the pathogenesis of atopic diseases such as atopic dermatitis, allergic rhinitis, and asthma. Resveratrol (RSV) exerts various pharmacological effects such as antioxidant, anti-inflammatory, neuroprotective, and anticancer. Although, it has been verified the beneficial effects of RSV on various subjects, the effect of RSV on thymic stromal lymphopoietin (TSLP) regulation has not been elucidated. Materials and Methods: Here, we examined how RSV regulates TSLP in HMC-1 cells. Enzyme-linked immunosorbent assay, real-time polymerase chain reaction, Western blotting, and calcium assay were performed to evaluate the effect of RSV. Results: TSLP production and mRNA expression were reduced by RSV. RSV down-regulated nuclear factor-κB activation, IκBα phosphorylation as well as activation of receptor-interacting protein2 and caspase-1 in HMC-1 cells. In addition, RSV treatment decreased the up-regulation of intracellular calcium in HMC-1 cells. Conclusions: These results suggest that RSV might be useful for the treatment of atopic diseases through blocking of TSLP.
Ground motions are used as input for the response history analyses of a structure. However, the number of ground motions recorded at a site located in low-to-moderate seismic regions such as the Korean Peninsula is few. In this case, artificial ground motions need to be used, which can reflect the characteristics of source mechanism, travel path, and site geology. On 15 November, 2017, the Pohang earthquake, with a magnitude of 5.4 and a focal depth of 9 km, occurred near the city of Pohang. This earthquake caused the most significant economic loss among the earthquakes that occurred in the Korean Peninsula. During the Pohang earthquake, valuable ground motions were recorded at stations distributed in the Korean Peninsula. In this study, a ground motion model is proposed based on ground motions recorded during the 2017 Pohang earthquake. The accuracy of the proposed model is verified by comparing measured and simulated ground motions at 111 recording stations.
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