ApoA1 enhances resolution of allergen-induced airway inflammation through promoting recovery of damaged TJs in the bronchial epithelium. ApoA1 could be a therapeutic strategy in chronic airway inflammatory diseases that are associated with a defective epithelial barrier, including asthma.

Inactivation of the ten-eleven translocation (TET) family members and catalyzation of 5-methylcytosine (5-mC) into 5-hydroxymethylcytosine (5-hmC) is associated with cancer initiation and progression. AMP-activated protein kinase (AMPK) is an enzyme that stabilizes TET2; however, the clinical relevance of AMPK and TET2 expression levels is currently unclear. Therefore, the present study aimed to investigate the clinical implications of AMPK/TET2 expression levels in colorectal cancer (CRC). Immunohistochemistry was used to retrospectively examine the expression levels of AMPK and TET2 in paraffin-embedded specimens obtained from 343 patients with CRC. The results demonstrated that AMPK and TET2 were highly expressed in CRC samples. No significant association was observed between the expression levels of TET2 and patient clinicopathological characteristics (age, tumor location, lymphatic, vascular and perineural invasion, Tumor-Node-Metastasis stages and differentiation); however, patients with low expression levels of TET2 more frequently presented with distant metastasis. By contrast, the expression levels of AMPK were significantly associated with lymph node and distant metastases. The survival analysis results revealed that high expression levels of TET2 were an independent predictor of favorable prognosis compared with low TET2 levels. However, no significant differences in overall survival were observed between patients with high and low expression levels of AMPK. These results described the clinical significance of AMPK/TET2 in CRC. The results of the multivariate analysis demonstrated that high expression levels of TET2 were a predictor of a favorable prognosis, whereas AMPK was not a significant factor for determining patient prognosis; therefore, further functional analysis of AMPK/TET2 expression in CRC is needed.

Nonlinear amplification is typically done on velocity signals from low-strain pile integrity tests to enhance weak echoes and superimpose any peak reflections. This conventional method may sometimes fail to untangle the hidden information within the signal that is obscured by the presence of noise. In this study, a pile defect identification system based on the conventional nonlinear amplification method and the wavelet packet transform (WPT) was proposed to easily detect the presence of any geometric or material defects by identifying feature parameters. Diagnostic rules, which have been lacking in the literature, were presented to serve as a guide in interpreting decomposed signals and in analyzing various characteristics of peak waveforms that are associated with certain types of defects. In this study, the finite element method was used to simulate the impact echo test of nine cases of defective piles. To verify the proposed scheme, six data sets of the nine cases of defective piles were made, in which a total of 54 piles were analyzed. The results of the study showed that the identification method based on WPT could detect defects 87.04% of the time compared to the conventional method, which only detected defects 64.81% of the time.

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