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The combination of capecitabine and cisplatin has promising antitumor activity and is well tolerated in patients with advanced biliary cancer.

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We report a gastrointestinal stromal tumor (GIST) patient with male gynecomastia and testicular hydrocele after treatment with imatinib mesylate. A 42 yr-old male patient presented for management of hepatic masses. Two years earlier, he had undergone a small bowel resection to remove an intraabdominal mass later shown to be a GIST, followed by adjuvant radiation therapy. At presentation, CT scan revealed multiple hepatic masses, which were compatible with metastatic GIST, and he was prescribed imatinib 400 mg/day. During treatment, he experienced painful enlargement of the left breast and scrotal swelling. Three months after cessation of imatinib treatment, the tumors recurred, and, upon recommencing imatinib, he experienced painful enlargement of the right breast and scrotal swelling. He was diagnosed with male gynecomastia caused by decreased testosterone and non-communicative testicular hydrocele. He was given androgen support and a hydrocelectomy, which improved his gynecomastia. The mechanism by which imatinib induces gynecomastia and hydrocele is thought to be associated with an inhibition of c-KIT and platelet-derive growth factor. This is the first report, to our knowledge, describing concurrent male gynecomastia and testicular hydrocele after imatinib treatment of a patient with GIST.

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This paper proposes a novel chattering free neuro‐sliding mode controller for the trajectory tracking control of two degrees of freedom (DOF) parallel manipulators which have a complicated dynamic model, including modelling uncertainties, frictional uncertainties and external disturbances. A feedforward neural network (NN) is combined with an error estimator to completely compensate the large nonlinear uncertainties and external disturbances of the parallel manipulators. The online weight tuning algorithms of the NN and the structure of the error estimator are derived with the strict theoretical stability proof of the Lyapunov theorem. The upper bound of uncertainties and the upper bound of the approximation errors are not required to be known in advance in order to guarantee the stability of the closed‐loop system. The example simulation results show the effectiveness of the proposed control strategy for the tracking control of a 2‐DOF parallel manipulator. It results in its being chattering‐free, very small tracking errors and its robustness against uncertainties and external disturbances

This paper presents an adaptive terminal sliding mode control (TSMC) algorithm for robot manipulators. The contribution of our control method is that the suggested controller can enable the advantages of non-singular TSMC such as non-singularity, high robustness, small transient error, and finite time convergence. To develop the suggested system, a non-singular terminal sliding variable is selected and does not have any complex-value or constraints of the exponent in conventional TSMC. Therefore, it prevents the singularity that occurs in the conventional TSMC and eliminates the reaching phase glitch. Accordingly, the suggested system can ensure that the controlled variables reach the desired values within a randomly known finite time using an efficiently smooth and chattering-free definite control input. In addition, sliding motion in finite time can be achieved by employing the adaptive self-tuning rules with no prior information regarding the upper bounds of undefined parameters (e.g., friction, disturbances, and uncertainties). Furthermore, the finite-time convergence and global stability of the proposed algorithm are proved by the Lyapunov stability theory. Finally, the proposed control algorithm is applied to the joint position tracking control simulation for a 3-DOF PUMA560 robot. The trajectory tracking performance of the proposed method is compared with those of the conventional terminal sliding mode control and the conventional continuous sliding mode control. This comparison shows the efficiency and superiority of the proposed algorithm. INDEX TERMS Non-singular terminal sliding mode control, robotic manipulator, adaptive self-tuning rules, uncertainty, disturbance, chattering behavior.

The combination of capecitabine and cisplatin was active and well tolerated as a first line treatment of AGC in general clinical practice. Disease status and performance status of the patients were the most important factors in treatment outcomes.