In the context of agricultural pest management, botanical pesticides are best suited for use in organic food (agricultural) production, due to their safety to humans and the environment compared to conventional pesticides. Compounds of plant origin can be highly effective, with diverse and multiple mechanisms of action, while having low toxicity towards non-target organisms. However, the large-scale application of these products for pest control is limited by their poor stability and other technological issues. An overview of botanical pesticides is presented in this paper. Trends and challenges in the research and application of botanical pesticides in Vietnam are also discussed.
Human hepatocellular carcinoma (HCC), the most common type of liver cancer, represents the second most common cause of death from cancer worldwide. The high toxicity and side effects of some cancer chemotherapy drugs increase the demand for new anti-cancer drugs from natural products. Mortalin/mtHsp70, a stress response protein, has been reported to contribute to the process of carcinogenesis in several ways, including the inhibition of the transcriptional activation of p53. This study conducted a molecular docking study of 41 phyto triterpenes originated from Vietnamese plants for potential Mortalin inhibition activity. Nine compounds were considered as promising inhibitors based on the analysis of binding affinity and drug-like and pharmacokinetic properties.
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