A new series of Schiff bases compounds that contains a set of one or more azomethine groups through the reactance compounds (3-Morpholino-1-(3-nitrophenyl)-3-(4nitrophenyl) propan-1-one, Terephthalaldehyde, Benzylidene acetophenone) with different aromatic amines (2-Aminobenzothiazole, 4-Bromo-2-methylaniline, 5-(4methoxyphenyl)-1,3,4-thiadiazol-2-amine, 4-amino-N-(5-methyl isoxazol-3-yl) benzenesulfonamide, 2-Aminoanthracene-9,10-dione, 4-(phenyldiazenyl) aniline, 5-(2chlorophenyl)-1,3,4-thiadiazol-2-amine, Melamine, P-Phenylenediamine) using glacial acetic acid as a catalyst agent (1-10). The synthesized compounds were identified using physical and spectral methods (melting points, colour change, Thin Layer Chromatography, infrared spectra, ultraviolet spectra and nuclear magnetic resonance spectra) and biological effectiveness has also been measured for some of the prepared compounds against the growth of bacteria, Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa. Compounds [1, 4, 7, 8 and 10] showed moderate antibacterial activity (inhibition zone 11-20 mm) on Staphylococcus aureus.

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