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These findings indicate that investigated biomarkers are constructive for early diagnosis of breast cancer and MMP-9/TIMP-1 ratio might be a new significant marker in predicting breast cancer development.

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Conversion from paper-based medical records to electronic Health Records provides significant benefits to healthcare. However, there are some challenges perceived by healthcare providers when implementing Electronic Health Records. This paper aims to present some guidelines to overcome barriers associated with implementing Electronic Health Records in developing countries. This paper also presents an overview of Electronic Health Records Barriers discussed in several studies and review some studies performed in developing countries to explore the implementation barriers of the Electronic Health Records.