Introduction Subjects with asthma-chronic obstructive pulmonary disease (COPD) overlap (ACO) share common features of patients with asthma and COPD. Our study was planned to describe the clinical and functional features of subjects with ACO compared to asthma and COPD patients. Subjects and Methods Study subjects who met the inclusion criteria were classified into three different groups: asthma, COPD, and ACO groups. All study subjects underwent clinical examination and biological and functional testing. They were then followed for 6 months to evaluate the response to conventional treatment. Results From March 2015 to March 2017, 76 asthmatic (mean age: 41 ± 22 years), 74 COPD (59 ± 13 years), and 59 ACO (52 ± 14 years) subjects were included. The percentage of subjects with dyspnea on excretion in the ACO group was higher than that in asthma and COPD groups (P < 0.001 and P < 0.05, resp.). Subjects with COPD and ACO had significant airflow limitation (FEV1) compared to asthma (64 ± 17% and 54 ± 14% versus 80 ± 22%; P < 0.01 and P < 0.01, resp.). The levels of FENO in subjects with asthma and ACO were significantly higher than those in subjects with COPD (46 ± 28 ppb and 34 ± 12 ppb versus 15 ± 8 ppb; P < 0.001 and P < 0.001, resp.). VO2 max and 6MWD were improved in study subjects after 6 months of treatment. Increased CANO and AHI > 15/hour had a significant probability of risk for ACO (OR = 33.2, P < 0.001, and OR = 3.4, P < 0.05, resp.). Conclusion Subjects with ACO share the common clinical and functional characteristics of asthma and COPD but are more likely to have sleep apnea. The majority of patients with ACO have a favourable response to combined treatment.
A cross-sectional study was conducted on 1,200 Khmer people aged 25-64 years living in Tra Vinh province to propotion of hypertension some related factors. 30 communes (clusters) were selected by probability proportional to size (PPS) method, evaluating their risk factors of coronary artery disease (CAD) in the next 10 years using Framingham scale in face-to-face interviews. Results showed that propotion of hypertension was 33.5%, inside, having 37.3% people don't know that they are getting hypertension disease. About some risk factors: 83.6% of participants had diet with less fat, 26.2% had adequate fruit and vegetable consumption, 10.6% had less-salt diet, 85.2% were non-alcohol abuse, 62.5% were non-smokers and 79.3% had moderate physical activity. About coronary artery disease: 79.7% of respondents have low risk, 16.3% with moderate risk and 4.0% with high risk of CAD in the next 10 years according to Framingham scale. The risk increases proportionally to the age and higher among men than women.
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