A novel
procedure for the Pd-catalyzed dual annulation reaction
to synthesize the norneocryptolepine derivatives involving the concerted
construction of two central heterocycles is reported. The further
methylation of the norneocryptolepine to afford its alkaloid analog
neocryptolepine implies that synthesis of various neocryptolepine
derivatives is feasible. The oxidative addition of Pd(0) is indicated
as the key step to activate the intramolecular addition of nitrile
according to the mechanism study.
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