Of the 12 cases, 2 (17%) showed eosinophilic globules in the typical cutaneous type of Kaposi's sarcoma. The globules were stained with periodic acid‐Schiff (PAS), periodic acid‐Schiff reagent after diastase digestion, and phosphotungstic acid hematoxylin (PTAH), but were not stained with Mayer's mucicarmine, and alcian blue. As the results, these globules might be glycoprotein. The shape of the globules was very similar to glycoprotein globules of yolk sac tumor (endodermal sinus tumor) in the tissue of the ovary and testis. In the yolk sac tumor, similar globules are stained with alpha‐fetoprotein, beta‐subunit of human chorionic gonadotropin, and alpha‐1‐antitrypsin using immunohistochemical techniques. Immunoperoxidase investigations were done with antibodies to alpha‐fetoprotein, beta‐subunit of human chorionic gonadotropin, alpha‐1‐antitrypsin, and carcinoembryonic antigen in the eosinophilic globules of Kaposi's sarcoma, but these antigens were detected in the globules. The morphogenesis of the glycoprotein globules is not clear yet. A better understanding of the source of globules in Kaposi's sarcoma awaits further research. ACTA PATHOL. JPN. 36: 1327–1333, 1986.
Summary
We injected 0.1 to 3 mg of morphine and atropine morphine added to 0.3% dibucaine solution into the lumbar subarachnoid space of 101 patients for supplementary intraoperative anesthesia and postoperative analgesia. Pain relief occurred within 20 to 40 minutes after injection and lasted 6 to 59 hours, with a mean duration of 25 hours, in 65 patients; the remaining 36 patients obtained unlimited pain relief for over 72 hours. However, increasing the intrathecal dose of morphine to 3 mg did not increase the duration of the analgesia.
Respiratory depression was observed in 5 patients who had recieved 1.5 to 3 mg of morphine and atropine morphine. Four of these patients developed delayed respiratory depression 5 to 8 hours after the injection, and one developed early respiratory depression 1 hour after the injection. All required treatment.
Other systemic side effects such as itching, nausea and vomiting occurred in a high proportion of the patients. However, in the majority of cases, these side effects were mild. A good euphoric mood appeared in 6 patients.
Our experience, although limited, is that intrathecal morphine can be simultaneously used with local anesthetics effectively, safely and simply. But the optimal dose has yet been determined, and requires further investigation.
The distribution of immunoreactive LHRH in the human ovary was examined using paraffin sections by peroxidase immunocytochemistry. Immunoreactive LHRH is seen in the granulosa cells of mature follicles, and in the theca interna cells of atretic follicles. But the immunoreactive LHRH is not found in the theca interna cells or stromal components of mature follicles, and in the granulosa cells or stromal components of atretic follicles. There may be a possibility that immunoreactive LHRH serves as a paracrine modulator in follicular maturation.
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