A practical and efficient approach for the total synthesis of the (±)‐lophirone F hexamethyl ether was reported. The compound was synthesized in 8 steps with a 14.6 % overall yield. The key features of this synthesis are the stereoselective synthesis of a 2,5‐diaryl‐3,4‐disubstituted tetrahydrofuran skeleton via a sequence of [3+2] cycloaddition/Krapcho decarboxylation and the installation of two aryl ketone groups bypassing potential epimerization of adjacent stereocenters.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.