two known lanostane-type triterpenoids were isolated from a new species, Antrodia cinnamomea. These three new compounds were identified as 4a-methylergosta-8,24(28)-dien-3,ll-dion-26oicacid [1}, 4ot-methylergosta-8,24(28)-dien-3,7,l l-trion-26-oic acid [2}, and 4a-methylergosta-8,24(28)-dien-3,l 1-< -7ß-1-26-: acid [3], by spectroscopic analysis. The structure of 1 was confirmed by X-ray crystallography.A new basidiomycete, Antrodia cinnamomea Chang & Chou, sp. nov. (family Polyporaceae, Aphyllophorales), the cause of brown heart rot of Cinnamomum kanahirai Hay. in Taiwan, was first identified in 1994 as a new species of the genus Antrodia (1). This organism is well-known in Taiwan by the name "niu chang ku" or "jang-jy" and is also a popular and very expensive medicinal material. The species is used traditionally as an antidote, an anticancer agent, and an anticnesmatic (anti-itching) drug, but no biological testing has yet been reported. In this paper we wish to report the isolation and
We describe identification of seven components from Antrodia cinnamomea. Their structures were determined on the basis of spectral analysis and comparison with authentic samples. These compounds include two steroids (1, 2) (β‐sitosterol and eburicol), two new steroids (3, 4) [methyl‐4α‐methylergost‐8,24(28)‐dien‐3,7,11‐trion‐26‐oate and methyl‐4α‐methylergost‐8,24(28)‐dien‐3,11‐dion‐26‐oate], two lignans (5, 6) [(+)‐sesamin and 4‐hydroxysesamin], and one long chain methyl ester (7) (methyl oleate). Among them, compounds 3 and 4 are first isolated from nature.
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