CT demonstrates large variations between individuals, but also at different locations within the posterior pole; substantial choroidal thinning inferonasal to the ONH was demonstrated. CT appears to correlate more with distance from the optic nerve than from the fovea and, thus, in future studies, the ONH may serve as a better reference point than the foveal center for expressing or depicting regional CT variations.
The quantification of drusen area and volume using an automated RPE yielded better agreement for volume than for area when compared with human expert manual segmentation. Using this software, drusen volume measurements may be a useful tool for quantifying drusen burden in clinical trials and clinical practice.
Automated classification of PEDs using internal reflectivity characteristics appears to be sensitive for detecting serous and fibrovascular PEDs. Automated classification and quantification of PEDs may be a useful tool in future studies for stratifying PEDs according to risk and possibly predicting the risk of advanced AMD.
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